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At the moment, a lot of different health problems are being lumped into ME/CFS. So much gatekeeping in ME/CFS seems to based on the assumption that there is reliable method of separating one subset from the others. The lumping is even more evident in LC (which to be fair, is intentionally...

Long covid patients might be motivated to deny the similarity because they're afraid that the association with ME/CFS could burden LC and prevent progress. I think they have an inaccurate view of how stigma and neglect works. LC is at very high risk of being stigmatized and neglected because...

I really don't understand the logic here. It's a bit like those people who seem to think that you can choose your reality. There is quite obviously a subset within LC that is very similar to ME/CFS and it doesn't help anyone to pretend otherwise. Some people think there is something to be...

It's the POTS. I also often feel like I'm doing strenuous work when in reality I'm just sitting there. I'm not as severely ill so I don't have to lie in bed much during the day. Low blood volume or blood pooling or similar things could create conditions in the body where the heart has to work...

Let's hope Chalder doesn't read the forum or she will very soon find this disorder is real, as proven by responses to questionnaires after CBT, and obviously best treated with CBT. And the best part is almost the entire population needs treatment. A real goldmine.

When I moved out of a dirty city into a beautiful town with many trees and gardens, my physical activity increased without having to force myself. Instead of the usual psychological view of the individual being the problem and somehow, 80% of the population being lazy, the low levels of...

I have no doubt that Ron's team is doing the best they can.

It's not a contradiction if he wants to test it against a sample of patients with the same illness, instead of a sample of patients with random illnesses.

Mitochondrial complex V is also called ATP synthase. A decline in its function seems like it would be a big deal (especially if this affects all cells). It's not the only source of energy in the body but it's a big one.

My interpretation is: in a previous study, their main finding was a mitochondrial complex V inefficiency, in cells that had been immortalized. Immortalization of cells is an invasive technique and they need to be sure that this complex V inefficiency is due to ME/CFS and not the immortalization...

I can see how it could easily happen in various ways, but it's a bit complicated to explain and some speculation is involved. It has a lot to do with systematic bias and nonuniformity of the illness. The idea is that covid-19 is expressed differently in every person, depending on factors such...

RT-PCR tests have varying reliability. For example their sensitivity depends on time passed since infection onset. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240870/ It's also possible that the tests are especially unreliable for long covid patients because their expression of the illness...

The long covid groups seem to believe that long covid is often associated with mild initial disease and not having antibodies on tests. Yesterday I read that antibody tests have low sensitivity in women. That could lead to an underestimation of long covid as the people with negative tests are...

The glutamine caught my attention because my mother says she needs to take glutamine before going to sleep or she will wake up from hypoglycemia or epilepsy (the two are connected). She has suffered from mystery illness for many years and also had postinfectious ME/CFS for a while and I suspect...

Would increased expression of proteins related to the actin cytoskeleton result in increased cell stiffness?

One for @Jonathan Edwards perhaps, because some strange cell signalling appears to be causing blood flow problems in the brain of covid-19 patients. https://jamanetwork.com/journals/jamaneurology/fullarticle/2776455

Why is this coming out now?

In Italy and many other countries society doesn't appear to have this derisive contempt towards ME/CFS that's seen in English speaking countries. Instead the main problem appears to be a lack of recognition and indifference. In the UK people in a way the topic gets more attention, more research...

I may have said it already but in Italy the term ME is generally not used. CFS still seen as a syndrome of fatigue (instead of a syndrome of exertion intolerance). Fatigue however appears to be more socially acceptable than in other countries. The desire to avoid having the illness associated...