Search results

What does minimum alternate allele frequency (expressed as fraction) mean? Does a value of 0.418 mean that 418 out of 1000 people have the mutation? Or that in 1000 people, there are 418 mutations (some of them homozygous?)

I wonder if a pathway like sestrin is malfunctioning in ME/CFS.

Interesting reasoning. Consultation-liason psychiatry doesn't seem to work. Since we cannot definitely exclude that it might work, we need a new generation of clinical trials testing a wider range of consultation-liason psychiatriy service models. Normally one would consider the apparent...

We should research the claim that repeated medical investigation is the cause of somatization or somehow causes illness by suggesting to patients that they are ill.

"not being able to" is not the problem, at least for me. It's the symptom exacerbation that occurs and it isn't improved with training. If we could increase activities this easily we wouldn't need any treatment because we could return to a normal life just by doing more. ;) Somehow Chalder has...

I know what study you mean. I cannot remember the details but remember thinking (I hope I'm not remembering wrong) the study came to this conclusion because it measured a limited of common symptoms. It didn't allow patients to openly describe all their symptoms. It seems almost inevitable to...

And why is this a problem? It's perfectly possible that for example hEDS is often just ME/CFS that was diagnosed differently because the patient happened to see a doctor that believed more in hEDS than ME/CFS. We should be trying to find out if this could be the case or not. The diagnoses...

What would be the danger?

I think we can assume that people are going to be biased towards reporting the symptoms consistent with the diagnostic labels they were given. However they also get the chance to report symptoms that are rarely mentioned in connection to the respective diagnostic labels and here we could be...

@Michiel Tack I suspect you're misunderstanding the goal of the study. I think it's meant to document what symptoms patients are experiencing and highlight symptoms that may be receiving little attention, as well as showing overlap between POTS, MCAS, ME/CFS, long covid. If there is a lot of...

The toxicity of the BPS psychiatric approach also generates distress and hostility in patients. Which is then cited as evidence that the patients need to be managed by psychiatrists. They cause psychiatric problems instead of solving them. Apparently their brand of psychiatry is primarily...

Maybe Sweden and Denmark can learn something from Norway? And I don't mean LP.;) The diagnosed cases are not the same thing as the cases that exist.

It's ironic that the BPS approach markets itself as being holistic and deep. In reality it's superficial and has a very narrow focus on the same few ideas that are applied to everything. An example is how the solution it proposes is nearly always CBT. In the case of ME the BPS approach even...

Potassium regulation during exercise and recovery https://pubmed.ncbi.nlm.nih.gov/1656509/ So the fatigue appears to hit fully when the potassium in blood returns to muscle cells.

One I think remarkable aspect of my fatigueability is that mental exertion can cause widespread weakness and fatigue in the rest of the body so that it visible affects my gait and walking speed. And similarly, after a walk I'm not very talkative because my brain is affected as well. Presumably...

A simple test might be to just count the studies reporting desirable effects and those reporting a lack of desirable effect. When researchers nearly always confirm their hypothesis or find their favorite treatment works then something isn't right because nobody is that good at solving difficult...

The recent posts and information here is intellectually stimulating. I realized that Vogt and I have vastly different experiences. When I first had symptoms, I did not think I had a chronic illness and carried on as much as I could. When they got worse and I began asking for help, I met...

It really is like gay conversion therapy. The goal is to make people stop believing that they have long covid or CFS or whatever. Presumably the driving force behind this is just the fragile ego of doctors who can't deal with the reality of having patients with an illness they don't understand...

It's funny how Vogt unironically goes on about the harm resulting from doctors carelessly spreading false ideas about illness, while spreading his own evidence-free ideas with large potential for harm. He apparently thinks it's ethical to label, without any proof, large groups of patients as...

A family member who is a doctor recently told me that he had a patient with pain everywhere and depression, on antidepressants. Her vitamin D level was 6 and this was the cause of her symptoms.