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The interferon gamma results were pretty similar for the controls across the two studies. If there was a difference with fresh versus frozen, wouldn't you expect frozen ME patient CD8 cells to be less likely to produce interferon gamma, not more likely than fresh? At least that's my naive guess...

Also interesting to see a difference in total cholesterol and what could be differences in non-HDL, d-dimer and hs-CRP (though not significant and the latter two depend heavily on the matching). But the matching looks odd, with big differences in smokers (18-28%), sex (32-66% female), BMI...

There's a fair bit of vague rehabilitation and CBT-ish programs in there, plus some weird stuff (like a million pounds for weight loss for LC), but the bulk of it just went to not particularly useful stuff, like CLoCk and many similar symptom studies, vague research about comparing LC treatment...

It does seem like something, but not clear what it might be. The data isn't really there in the paper, but it doesn't look like the CD8 results correlate with symptoms. ME/CFS patient 1 (clearly Selin herself) had very low cytokine production for the "mean of 3 time points over 3 years prior to...

I think if inhaling β-Caryophyllene was hugely helpful for ME or LC, we'd know by now as it is present in significant concentrations in cannabis.

If you look in the PDF, not only are two of the authors the inventors of this concoction, but two of the authors are also patients in the case series. Good to see also that one of the few R01 grants for ME/CFS research is being used for this kind of thing.

Glutathione, NAC, B12, Eucalyptol and β-Caryophyllene (which is apparently found in cloves, rosemary, cannabis, hops, etc), according to their patent application. Apparently it treats COPD, Asthma, COVID-19, Long-COVID, and ME/CFS.

Putrino says: "If you give someone with no persisting pathogens, but an overactive immune system that is producing antibodies for a particular virus, an antiviral that boosts immune function, they will get sicker because the last thing they need is more immune activity." I think the antivirals...

It would be fantastic for someone to study PEM caused by cognitive exertion in more detail. Enrol people who experience PEM from doing mental work while lying in bed, get them to do so in a clinical setting and see what you can observe. Even better, provoke PEM both physically and mentally in...

The author seems to be pining for the days when they found the targets entirely by chance, which is pretty clearly a strategy with diminishing returns.

To me, it feels like whatever process causes mental fatigue in normal people causes PEM in ME, just at a much lower threshold. Why is it tiring for someone to play in a chess tournament all day? Why is it tiring for an introvert to have video meetings all day? Whatever is going on there seems...

They did adjust for daily hours spent socializing. But I wouldn't discount that it might be a case of more conscientious students were less likely to get Covid and more likely to get top marks.

I think it does make political sense to focus on SARS-1 and MERS, though it probably wouldn't hurt to mention ME too at this point. In 2020, if you wanted to know about the likely long-term effects of SARS-2 to drive your pandemic response, the studies covering post-SARS-1 were much more useful...

Anecdotally, this matches my own experience very well of the early days of ME (once as a teenager, once more recently). One thing that was quite notable to me at the very start in both cases was a distinct inability to output the expected power from my muscles while biking or cross-country...

More strong evidence that we need to start looking a lot more closely at muscle and microvasculature to figure out why patients aren't able to extract oxygen from their blood. Pretty clear the problem isn't in the heart or lungs. Also, this is good: "While deconditioning is commonly suggested...

I think they did report the results recently. Does anyone have a PDF? Would like to see what specifically they sequenced and looked for.

That sounds pretty neat. Does a pathogen-specific T-cell detection array exist or is this something someone needs to build? Somewhat relatedly, I've been thinking that maybe we just need to sequence patients' blood (RNA and DNA) and see if any known pathogens comes up in patients more than...

It's been interesting to see Al-Aly and crew start out with flu as a control versus Covid in their earlier papers and then come to realize that actually flu is quite bad too and has post-acute consequences. Hopefully he manages to bring others along to this understanding.

Has anyone looked at oxygen delivery to muscle or oxygen consumption in muscle on multiple days following exertion? Basically something similar to the two-day exercise test CPET, but looking specifically at oxygen in muscles.

10y+ duration was also associated with severity, as was age and being female. Is it possible that it has become easier to get an ME diagnosis in the UK in the past decade (or even two decades)? If that were the case, I can see two possibilities: severity is associated with infectious onset and...