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I think the headline is that the risk of post-Covid sequela is higher after a second infection than a first one. So risk for Long Covid is higher after a reinfection, not lower as many have assumed. Risk of at least one sequela (excess over control group): 1st infection: 8% 2nd infection: 23%...

They just posted a preprint for a follow up using the same data set, this time on post-Covid sequela after reinfections: Outcomes of SARS-CoV-2 Reinfection First infection with SARS-CoV-2 is associated with increased risk of acute and post-acute death and sequelae in the pulmonary and...

Looks like they plan genomic sequencing of this cohort and expanding to more patients in the future:

The very brief PHQ-2 might be best for depression in ME (or Long Covid, etc) and is already well known: Over the last 2 weeks, how often have you been bothered by the following problems? 1.Little interest or pleasure in doing things 2.Feeling down, depressed or hopeless Though even question 1...

It seems like elevated kynurenine is found in all kinds of disease (including, for example, heart disease) and might just be a sign of inflammation in general.

It looks like the first result is looking at a binary variable: having one or more first degree relative with AID versus having none, so I don't think that would be an issue for that result (the first OR 5.30 one).

I found the poster for this study, which gives a little more detail, including the list of auto-immune diseases: Interesting to see they selected only ME patients with acute onset following infectious disease. This definitely needs follow up, since it is such a small study. But the good...

From the introduction: In paper I, the main goal was to follow up previously performed work by our group that reported associations between ME/CFS and HLA-C: 07: 04 and HLA-DQB1: 03: 03 alleles. The HLA (human leukocyte antigen) region consists a multitude of immunologically relevant genes in...

I've seen a number of people wondering on Twitter why they found spike protein, but almost never S1, given that you'd expect S to be cleaved into S1 and S2.

Abstract Background: Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a disabling multi-system complex disorder with prevalence of 875 per 100,000 (up to 3.4 million people) in the United States. There are no known etiologic or risk factors and no approved treatments for ME/CFS...

Interesting to see low manganese come up given the low manganese in hair samples from Ron Davis, but with 11 patients, who knows how meaningful that is. They must have been testing a lot of different nutrients, so they were bound to come up with some "significant" differences below 0.05 just by...

Objectives A comparison of the nutritional biomarkers between ME/CFS subjects and healthy controls (HC) was undertaken on secondary data collected from an IRB approved cross-sectional study in ME/CFS patients. Methods ME/CFS participants were recruited per the 2018 revised Canadian Clinical...

Also, there has been a more recent, sufficiently-powered, study on CBT for dissociative seizures which found no difference in the frequency of seizures with or without CBT.

I wonder if anyone has looked for antigens from the usual viral suspects in ME plasma. Obviously there have been lots of antibody studies, but have any studies done what was done in this study, i.e. an assay for specific antigens from a suspect virus? For example, it might be interesting to see...

They found spike in 60% of 37 PASC patients' plasma, at some point 2-12 months post-Covid, but in 0/26 recovered from Covid without PASC (10 admitted to ICU).

The diagnosis and management of post-acute sequelae of COVID-19 (PASC) poses an ongoing medical challenge. Identifying biomarkers associated with PASC would immensely improve the classification of PASC patients and provide the means to evaluate treatment strategies. We analyzed plasma samples...

I'm seeing more and more of this kind of unfortunate over-estimation of the risk of Long Covid. It's definitely not the case that 30% of people who get Covid will have disabling LC for any reasonable definition of disability.

They are certainly hanging a lot of conclusions on blood from 4-6 people there. I wonder if there is some effect that people who were more likely to be re-infected after three doses and a past infection probably just have weaker immunity in general, so the causality might be running the other...

An interesting point from the latest report is that 37,000 more people reported Long Covid on May 1 versus April 3 who first had Covid in the pre-Alpha period. So that's 37,000 people who probably are now reporting LC after a recent Omicron re-infection (181,000 more reported LC after a first...

Interesting data point regarding incidence of CFS: 0.63% incidence over 12 years for adults. No idea how hard it is to get diagnosed in Taiwan, but it's another data point. Also interestingly only 53% female. Age at diagnosis 51 ± 18. FM comorbidity 78% Dyslipidemia 36% T2DM 23% Comorbidities table