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I'm quoting myself because I found something of interest on the medulla oblongata. Turns out it has been researched in ME/CFS already, and one study found that this part of the brainstem doesn't communicate very well with the other parts of the brainstem during exertion. From Health Rising: "It...

This quote sounds very logical based on my subjective experience with the illness: "We believe that the clinical symptoms in ME/CFS suggest inadequate autoregulation of blood flow according to the demands of tissues, resulting in tissue hypoxia. This is associated with lactate accumulation from...

Found a really great Twitter thread by a Norwegian Psychology Professor called Jonas Kunst. He's got some very good points regarding the authors weak adjustment for multiple comparisons:

Come to think of it, I think Phair and Davis mentioned that they think the cells stuck in the metabolic trap are immune cells... It doesn't say which cell types they've gathered in this study, as far as I can see.

This is what Jonas Bergquist in Sweden is trying to find out. He's looking at kynurenine as a treatment option in a trial that's underway.

I'm wondering if Robert Phair and Ron Davis have seen these findings yet. The Kynurenine Pathway is an important part of the "Metabolic Trap"-model they've been working on. The model predicts that kynurenine is missing in some parts of the body/brain, and this could be behind many of the...

This is a very important point. I see so many CBT/GET proponents who present it as: "you either start GET and CBT, gradually raise your activity level and recover, or you lay in the darkness 24 hours a day for the rest of your life - the choice is yours!". And most of the time they aren't even...

This is very interesting, thanks for sharing. Any research that provides nuance to the current medical dogmas around exercise is always good. E.g. "exercise is always good, no matter what condition" or "exercise is the closest thing to a panacea we've come across, with no possible side effects...

Very well put. I think you're at the core of the issue here. When I was healthy and studying social psychology I came across two theoretical concepts that I think are relevant when it comes to explaining how doctors treat ME-patients: 1) The Just World Hypothesis - the belief that people get...

That's so sad to hear, but I don't doubt it for a second. When was this? That's a good example of the direct damage that the faulty BPS-model and the fraudulent trials that have "validated" it has done to patients.

I haven't gotten to look into the details yet, but at a glance this makes me think of Jarred Younger and his research into ME and fibro. He's gotten a grant to look for neuroinflammation in ME recently (from the NIH I think?), and I read once about his idea that "hyperactive"/"angry" microglia...

Good, this story should be told multiple places on this forum. It's too important to be missed. Would love to know some more about this event. Are there any other doctors we know about that attended this event or similar events? I don't doubt the veracity of Dr. Hyde's claims, but it would...

A reference list has been added to the video as well. Lot's of good sources and it backs up the claims made in the video. Here's a direct link: Kilder ME-skandalen del 1.pdf - Google Disk

Do any of you know any more about this story? From Byron Hyde's facebook. Quite a disturbing read: "“Several years ago I was lecturing in British Columbia. Dr [Simon] Wessely was speaking and he gave a thoroughly enjoyable lecture on M.E. and CFS. He had the hundreds of staff physicians...

It looks like I'm a lot more positive to the Metabolic Trap Hypothesis being a possible explanation to ME, than a lot of others here. But I'm curious, those of you who are very sceptical and have almost discarded it already, have you actually taken the time to try to understand the model on a...

I feel some temporary relief taking Niacin (a vasodilator). Niacin is also hypothesized to be involved in The Metabolic Trap Hypothesis. It's made from NAD, if I remember correctly, which in turn is made from kynurenine, which the models predict is what's missing.

This is an important point. I just came across a Twitter-thread that was a very good example of this. It's from how the Telegraph reported the results of the PACE-trial in 2011. It's an extreme misinterpretation of the findings and it shows just how bad it's been: Adam på Twitter: «Graded...

Thanks for all the replies thus far, lots of valuable insights and thoughts! I really think that if we could get someone with a sound knowledge of these methods to apply them to the evidence base and evaluate it systematically, and publish the findings in a peer reviewed journal afterwards, it...

According to Cort Johnson oxidative stress has been one of the most (if not the most) consistent biological findings in ME-patients, found by the research groups who have looked for it, so I definitely think it's an interesting aspect to take into consideration. And it seems probable that it is...

Just a wild guess, but if the researchers who think neuroinflammation is a part of the picture are correct - could it be that the steroids temporarily lowered the immune activation in the brain, thereby restoring more of the normal function? From what I understand, some researchers (e.g...