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The studies I quoted are 10 years old, so I don't think they changed anything in terms of diagnostics, unfortunately. I have tried to find hints as to why this research hasn't gone further - as the same group published several papers on sleep from 2003 or so on - but haven't come to a conclusion...

I don't follow your logic here to be honest, sorry. Hope you can help me understand you! (1) What makes you believe that different sleep architectures between pwME and healthy controls are not "universal"? All the data I have seen these past days point towards a consistent difference...

Interesting, thanks for sharing. I don't think I perceive my sleep any better or worse when I have PEM or a flu. As in, I don't wake up more often or have any more insomnia. I wake up feeling less rested though. With regards to separating unrefreshing sleep and sleep disturbances (I guess you...

I was under the impression, that I provided several pieces of literature that indeed show evidence for an increased amount of microarousals (and reduced US delta power in SWS) during sleep in pwME. I thus don't fully understand what you are trying to tell me, sorry. Microarousals, as far as I...

Seems like this is a follow-up study of the EEG study I quoted in my previous post. Excerpts of the discussion sound interesting: I like the sound of the idea regarding homeostasis. I wonder whether the increased amount of SWS seen in pwME is due to the body trying to counterbalance the...

Some quotes from this study from 2014: I myself don't know what diagnostic criteria for ME are state of the art currently. Results table: The amount of SWS (slow-wave sleep) and sleep fragmentation (MAI) seem to be higher in CFS: *excessive daytime sleepiness However: Interestingly...

Alright. So what if your good quality night baseline (i.e. the nights that are not obviously bad) is full of microarousals that you don't perceive leading to fragmented sleep architecture (as has been shown in several studies for pwME)? I am trying to dig through the literature, but too brain...

Great that it at least helped for the menopause symptoms! Interesting, thanks for contributing! How you you measure your "sleep quality"? Using my smartwatch + Zepp/Notify for Amazfit and also my Polar verity sense armband + Sleep as Android, I can clearly see a stark increase in deep sleep...

Thanks for sharing your experience. Do you remember how much you took, when you took it and for how long? This is certainly the case with benzodiazepines, they do not improve deep sleep for example. But I don't think it's necessarily true for all medication - I wouldn't know why it would be...

I used propranolol for POTS for a while and it definitely maybe me more sleepy, but I don't recall waking up more rested, unfortunately. I am mild most days, used to be moderate. Responding to a deleted post about good sleep being helpful. 100% agree. Makes me wonder how (1) how much of the...

Hey guys. I am wondering how much properly addressing sleep disturbances in pwME would help with symptoms. By properly I mean addressing the proposed mechanism that is out of whack in pwME, leading to unrefreshing sleep. From what I can tell from reading this review vertically (Table S3 for...

Yes, you're surely right. But death is the biggest risk in driving a car as well. I wonder what the chances are to die from daratumumab (and not multiple myeloma eventually)? And then, realistically, what other risks there are besides death. I suppose IVIG would be a way to reduce infection risk?

Realistically, what are the risks of participating/taking this mAb? Sure the immune system will be down for a little while, but it should recover fine, right? What are the biggest realistic risks?

Also interested in more info!

I have seen the same effect of pregabalin or gabapentin. I am wondering though if it's just a higher dose making you feel good/high and masking symptoms or whether it's actually temporarily "healing" the symptoms.

I found this guy's videos quite nice during my Master's: https://www.youtube.com/playlist?list=PLqTetbgey0ac_tvd5WeTOYqUPECW4NmnY

Purely mechanistically, would we expect something like nighttime clonidine to increase nighttime HRV and thus potentially aid recovery? Or would something like pyridostigmine mechanistically be of more help? I haven't been able to read the study and am wondering if they hypothesize whether its a...

Yessir.

And I never said that you said that I said... I guess you see this rhetoric leads us nowhere. From your other comment I read their reasoning, but personally not convinced their reasoning makes much sense. Thanks for the excerpt!

That's not the point I'm making. I never said their trial design is optimal, I merely used them as examples for 40 sessions seemingly being the latest or most used protocol. Hence, 10 sessions seemed little.