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But the person asking the question (I believe it was Prof Birgit Sawitzki) said that for autoimmune diseases the side effects are much more benign than with cancer (which is what Fluge was basing his reply on iirc), right?

Seems like they've had a pilot study beforehand? And a review that seems to address this (haven't read).

The drug used is also known as Imunovir. I remember some trials for ME in the past? And also that it's very expensive in the US and dirt cheap in Europe. And that a member here had bad results?

Introduction. After the acute form of COVID-19, 10 to 30% of patients tend to develop a post-covid syndrome or long-COVID-19. Research is actively being conducted into the causes of long-term COVID-19, one of which may be a violation of the immune response after SARS-CoV2 enters the body as a...

Important to add that he himself showed this data only tentatively. Saying that it might well be chance, but with their small cohort they have seen this correlation. Thus going forward, to more successfully meet endpoints, they will introduce NK cell amount as an inclusion criterion.

This is baseline, pre treatment. Additionally, in the responder group there were only moderate and moderate/severe patients. The 2 severe patients in this study did not respond.

Wasn't sure where else to post this, but this Bio-Sig PEM study seems quite comprehensive.

This slide was shared today at the ME/CFS conference in Berlin, on the basis that B cells need T cell (th) signals in order to mature. They thus checked if those signals are changed leading to potential autoimmune processes in pwME. Dubbed "plasma proteome of b/t cell secreted molecules". Very...

Here are the screenshots - I hope it's OK to share them here. Papers in preparation it says. So they seem to have seen decreased sleep spindles in long COVID patients. Some potential correlations to ACE2-AAbs and serum MDA. Will be interesting to see the bigger cohort where they will in...

This is the baseline, could you also share the table they showed for after treatment? I think it even went up to 15000 if I recall correctly?

There was just a presentation of the "Sleep-Neuro-Path" study in Germany. More info here. Will share some screenshots of disturbances they found in (if I understood correctly) studies done before this new study. Seem to have found a difference in sleep spindles in NREM2 and will now look deeper...

Interesting angle! As an analogy, would you in that case contribute e.g. impaired working memory with running out of RAM to process/save new information? Though the brain surely is more complex than this analogy would make it sound. Do you know in which sleep stage this complement-mediated...

Pharmaceutically, I believe there is reasonable evidence for certain drugs to be able to modulate this. Also within the 'inverted u' for sleep microarousals of the Lüthi paper I linked various times. Selectively through deep brain stimulation or something like that, I have no idea of. Drugs...

Fluge will present "Plasma cell targeting in ME/CFS" in a couple minutes.

Sounds interesting indeed! Much appreciated!

I found the immunological block quite interesting today. Has anybody followed it? @Jonathan Edwards maybe?

For what it's worth, in the PEM conference the other day, I believe three different groups (Putrino, Puta and another one) showed either preliminary or clinical data from their clinics - all of them seeing increased plasma lactate during rest and activity compared to healthy adults. It was...

I don't know if the talks were recorded and will be shared.

I'm not sure anything new or groundbreaking has been shared. Amongst different clinical or scientific groups, they found an increased active and resting lactate level. Beta 2 receptor involvement (and thus potentially autoantibodies) in exercise-induced lymphocyte migration was mentioned by...

I am not hypothesizing that "symptom severity" was due to this. I am questioning the pathophysiology of unrestful sleep and questioning whether this symptom can't be tackled adequately by specifically addressing the differences seen in PSG. Again, if infraslow power and microarousals play a...