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So, the box are the quartiles, right? Meaning in that bar it looks like all the patients in the mid 50% of the Gauss curve had a score of 2. Then there's outliers making the error bars which are the 95% CI of the mean?

Good question, looks like they might have deleted outliers that would have messed with statistical significance? Any other reasons?

I'd guess the most likely reason would be that "immune response" is a very broad term. ARDS is caused by a cytokine storm (highly elevated levels of pro-inflammatory cytokines) from what I remember - this is an overactivation in that case. Here, it seems like the antibody response against SARS...

Probiotic improves symptomatic and viral clearance in Covid19 outpatients: a randomized, quadruple-blinded, placebo-controlled trial 2022 study ABSTRACT Intestinal bacteria may influence lung homeostasis via the gut-lung axis. We conducted a single-center, quadruple-blinded, randomized trial...

Hey! I'm interested in hearing your experiences with "tired but wired". I'm wondering if everybody is talking about the same (or similar) experience. How does it feel to you? When does it happen? Is there anything you can do/take to help in your situation? Do we know the pathophysiology behind...

Interesting. It does seem though, that MAO-B is more active in both papers, one being a human trial? I'm not very familiar with this though, so I'm wondering what else (besides their ideas about astrogliosis) could be reason for getting such a result (methodologically or pathophysiologically)...

Is there any new info on how/why this is supposed to work? And why it poops out on a group of patients that seemingly had gotten better? And any knowledge on how to optimize effect and length of effect/avoid poopout?

I figured, but thank you for your assessment in any case :) I am wondering - as I lack knowledge/education in this field - why this line of thought linking MAO-B and LC (and mitochondrial energetics) is not looked into more. Well spotted!

Is there nobody here that can discuss this a bit? :)

This paper seems related? Background After acute COVID-19, 5% of people experience persistent depressive symptoms and reduced cognitive function (COVID-DC). Theoretical models propose that astrogliosis is important in long COVID, but measures primarily indicative of astrogliosis have not been...

Have there been any updates on this? Any opinions?

I would see it a bit more nuanced, but fair enough. :)

It's very subjective, that's definitely true. I'm sure it also depends on the baseline one has. I'm mild, so my anecdotes will have nothing in common with moderate or severe patients. What seems to help me with my threshold and recovery is dextromethorphan. I've managed to go on some easy treks...

I don't know where to ask or to look for it but I was wondering if there's a list of treatments that people use to help with PEM? Either to avoid it, to increase threshold, to increase rate of recovery, reduce symptoms etc?

Not to sound pedantic, but a typo in the first sentence of a paper published in Nature Sci Reports? "syndroome"

Good point! If I understood the concept correctly, the main efficacy is supposed to come from the inaudible frequencies of the chair that stimulate Pacinian corpuscles and not from the sound listened to via headphones. I'm not sure how or if this would be affected by external factors such as...

Yeah, I am not sure how much you actually feel it, but you could just tell the participants that it's barely noticeable, if at all - so the placebo receiving patients don't realize it's placebo. Another way would be to use different frequencies or amplitudes in both groups, or as you say a dose...

Probably not, but let's see what the study says once it's out. Do we know of any similar studies in which stimulation of the Pacinian corpuscles is supposed to be therapeutic in the context of ME or LC?

Looks like this study has also showed similar results: Edit: posted elsewhere https://www.sciencedirect.com/science/article/pii/S2405500X2300806X

100% agree. LC could be anything really and without being able to scrutinize their methods, it's impossible to know what patients they included (and how many). I hadn't thought about PEM, as listening to music is fine for me, but it's true that the vibrations could elicit such a response. I'll...