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Yes, the CSE1L RNA is found all over the brain. LINK to Protein Atlas. I reviewed AI answers on tissue function and the most likely answer based on what we know of ME/CFS is: I checked in GeneCards and it has this sentence : "In addition, the encoded protein may play a role both in apoptosis...

Gunnar Gottschalk and Avik Roy from Simmaron are authors, hence the focus on ME/CFS. They are the ones that highlighted a difference in ATG13 in ME/CFS and running the clinical trial with rapamycin in ME/CFS.

I think that story might tie in well with the BTN2A2 and BTN3A3 seem to have a similar role in gamma delta T cells.

I've not seen much in the US press that I read so far. Usually ME Action do a very good job of spreading the word for major ME/CFS news. I think a genetics story would be very powerful if it included a mention of the Stanford WGS study that also highlighted the immune and nervous system. That...

@Jaybee00 There was a message from the mods the other day that it would be helpful to add a follow-on post on how this is relevant to ME/CFS. I think it would be helpful as I can't figure out the link. Many here can't read blocks of text very well. I find it helpful when the author of the posts...

I think it might be a good idea to add BTN3A3 to this thread @Hutan as they linked the two in the report above. BTN3A3 has increased expression and BTN2A2 has decreased expression.

Note from above. Decreased expression in ME/CFS. Summary from Google AI RABGAP1L: A Rab GTPase-activating protein 1-like protein with diverse roles RABGAP1L, also known as TBC1D18, is a member of the TBC domain-containing protein family involved in the regulation of small membrane-bound...

Has there been any comment of the previous finding of SLC25A15 in women in the UK Biobank ME/CFS dataset highlighted in the Joshua Dibble thesis, a member of Chris Pontings team. I couldn't find a reference in the new paper. Would be interesting to know the p-value in this study.

Thanks for posting the video again. This was really good. That team is creative, smart, adaptable, and able to get things done. I liked how he had complete answers to questions, none of this "I'll need to get back to you". And he collaborates and recognises others work. I really enjoyed the talk.

The Seahorse testing only used a small number of patients. Talking to researchers who've measured PBMC's, and the Rybeck myoblast paper showed, individual results are either high, low, or average. If you use a low number of patients the mean could be anywhere. So I don't think we should read...

It is amazing all the techniques available with PET scans. In ME/CFS researchers are still only scratching the surface. I was reading that you can even monitor blood flow in different areas of the brain. I wonder what neurotransmitter PET would show in ME/CFS?

I took a quick look at PET research into migraines. They are using all sorts of different techniques to try and understand what is going on. It feels like in ME/CFS we are still in the dark ages with the techniques and sample sizes being used in comparison.

I sped watch some parts. I guess we need to wait until the paper is published for a proper read and comparison to controls, and also MS reference data he has access too. Not all ME/CFS patients showed activated microglia. The bits I watched didn't describe if controls had some activation too...

I'm wondering if we could gather some ideas on how to create threads around the DecodeME results and paper release so that we can manage the explosion in number of posts, and any interesting posts are easier to find again in the future. For reference this thread is already at 44 pages. For...

When I looked the other day I couldn't find good information. Most of the information returned in my search related to absolute levels. I think diabetes and cholesterol kept coming up, and I think there might be lipid changes in diabetes, but I couldn't find detailed info on network correlations.

One universal finding in metabolomics studies in ME/CFS is that there is something going on with lipids but it seems we are not quite sure what this is and the reason for it. Steroid hormones are lipids. If we were to consider the lack of correlation between certain steroid metabolites in...

What has fascinated me about hormone levels in general is that they are often higher at waking and then decline during the day. It made me wonder how the body copes with so much variation. At the back of my mind has been the thought that perhaps the body must like to maintain a ratio between...

Could this 2021 paper be of interest in relation to this study. Thread : Hypothalamic-Pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome, 2021, De Bellis, Montoya et al Paper : LINK

This. Your notes get added to the file, even if you don't see them. What you see online on your record is often different from a full records request.

In the US if you are under 50 it is much harder to get disability as it is written into policy that people can retrain for other jobs such as sedentary ones. At 50 and above this requirement is less stringent. As for medical records noting appearance, attention, alertness, that gets written...