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YouTube Description Join Emma Wall, a Senior Clinical Research Fellow at the Crick as she explains the science of long COVID, who it affects, its symptoms and how it can be prevented and treated. Long COVID has affected up to 2% of the entire UK population in the last five years, but we still...

There is some discussion of IFNγ in the "Aging and Alzheimer’s disease" section of the paper regarding mouse models.

Received via email about a new book download with a link to an online 3 day event on 17-19, July 2025. Sharing only so people know what so called experts are presenting as fact. Email Contents ME/CFS affects 2.5 million Americans, yet 90% remain undiagnosed. For decades, patients have searched...

As a counter point we should mention that seeing a specialist in the US without insurance is incredibly expensive. Even a recent GP appointment (in a large medical practice) with bandage wrap as treatment supplied was $1000+ before insurance discount, and after discount I was left to pay $225...

I went looking for Dr. Younger publications in ME/CFS as he has weekly video's that many with ME/CFS watch. I didn't find any neuroinflammation papers on ME/CFS from him. The only ME/CFS one was one on Possible Racial Disparities in the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue...

Participants could select from the following options: (1) Headache, (2) Facial pain, (3) Neck or shoulder pain, (4) Back pain, (5) Stomach or abdominal pain, (6) Hip pain, (7) Knee pain, (8) Pain all over the body, (9) None of the above, (10) Prefer not to say (UK Biobank Questionnaire field ID...

The main repeated SNP's in Table 3 with highest p-values is for variants on gene ARHGEF28, I looked up the gene on GeneCards (link) to determine function. Interesting that ARHGEF28 is a gene that has function for brain signalling related stuff (synapse formation and dendritic morphogenesis)...

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...

Here is the list of genes highlighted from the Supplementary section.

Still, the general conclusions were interesting. I also learned from the paper that there is data in the UK Biobank GWAS database for widespread chronic pain. Tagging @Jonathan Edwards in case it is of interest. EDIT: I created a thread for a GWAS study on widespread pain Genome-wide...

Liz Worthy at UAB had a SolveME funded project looking at WGS in ME/CFS https://solvecfs.org/research-and-registry/ramsay-research-grants/meet-the-researchers/elizabeth-worthey-and-camille-birch/ Here is her LinkedIn profile https://www.linkedin.com/in/lizworthey/

Here is the UK Biobank public GWAS data on Fibrolmyalgia. Trait Info : 656 cases. http://geneatlas.roslin.ed.ac.uk/trait/?traits=491 Here is the P-Value table with P=1e-08 cutoff. Unfortunately all the MAF values are rare, so would likely not meet quality control in a paper...

I posted this study after reading the following comment on a Fibromyalgia thread

Genome-wide association study of multisite chronic pain in UK Biobank, 2019, Johnston Abstract Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype...

Two studies come to mind. 1. Prusty found you can have viral proteins without replication that could cause an immune response. For HHV6A he studied U40 (a small non coding RNA I think) as a marker for latent reactivation. He then showed how that can affect model cells in the lab. 2. Jackie...

Ron Davis holds the yearly Stanford closed working group meeting with 80+ attendees in early September. I don't know the date and the meeting is not public. The Stanford meeting is focused on how the key findings presented by researchers (some pre-publication, hence closed meeting) link to...

I asked Google AI "". This was the No. 1 answer which seems to tie in with the Beentjes paper findings. If this occurs in the skin as well it could be the reason for peripheral neuropathy similar to diabetic neuropathy? I hope the Dr Systrom study looks for capillary basement thickening in...

It's well worth reading the Sick Times article. I really feel for patients that just had surgery/treatment and then hit with these new fees, wondering who will support them with the recovery stage, especially after major surgery.

Attached is the newsletter from the new practice Dr. Ruhoy founded called Anthurium. It has instructions for new and existing patients and the fees (excluding any treatment) mentioned in the Sick Times article (also LINK). The link to the newsletter is also on the Anthurium web page.

From the preprint: @DMissa Do you have data from your LCL cell lines on Ca2+ and SOD2 to perform a calculation for comparison to lymphocytes in the Stanford study? Note: I came here from the SOD3 discussion on the Beentjes UK Biobank paper thread where SOD3 was found lowered in both males and...