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I was surprised that they noted Granzyme A and not Granzyme B. Can you remember what Jackie found regarding Granzyme A vs B? Background :

After chatting to AI I can think of no obvious reason for the profound disruptions of the links between the hormones as many of the links are based on biological processing pathways e.g. more of one hormone leads to more of another hormone in the same pathway. It seems like the feedback...

Dr Jackie Cliff provided an update on NIH funding concerns. Her team has had long term funding from the US NIH for research and her lab provides services for the UK ME/CFS Biobank.

Carmen Scheibenbogen and Klaus Wirth have a hypothesis on calcium overload in ME/CFS. LINK

From the OMF website: Source

Was meant to be a joke - the horse was lying down representing PEM symbolically. At conferences people start to fall asleep, stop paying attention so he likes to lighten things up, I guess to get people to listen or remember what was said.

Lucibee on X wrote : Dr Alexis Gilbert has outlined what the Final Delivery Plan for ME/CFS *should* have looked like (on IG): https://instagram.com/p/DMa8sjPMzd2/

Disease controls, fatigue, no PEM, patients from clinic with heart disease, PAH etc who also have CPET data and are fatigued.

An update on the Bioquest study starting at 10:43 in the video by Dr Jonas Berquist at IIMEC17. Currently open to suggestions on what markers to add - including immunoassays. @Andy might be an opportunity for @Chris Ponting to ask to include some protein targets for DecodeME vallidation.....

Dr Systrom talk starting at 11:41 is very interesting. Preliminary partial data showing reduced mitochondrial biomass in muscle and / or reduced electron transport chain in some with ME/CFS. This is related to the reduced oxygen uptake see on the CPET test in a subset. Preliminary data, study...

Cohort details - Similar case size to DecodeME.

This is a Nature Preprint Hosted on Research Square. Link | PDF

Versus Arthritis funds fibromyalgia research. Many with ME/CFS could also get / have a FM diagnosis.

An ME Action email today stated that Jaime Seltzer is working hard on an unnamed big data study. I hope that means that the Crash Course study is nearing completion. This will be a good test of wearables to see what kind of information can be gleaned from them and if anything correlates to...

My hope is that if there are clear leads, we can use the contacts gained through developing this delivery plan to really emphasize the need to follow up DecodeME leads. People want to be winners, and to be seen taking action. If we have specific targets that make sense, everyone becomes a...

This This This This This This Having a clinic with interested and curious clinicians backed by researchers is key! It's one reason why I posted this video by a researcher outlining the same issue for ME/CFS as for diagnosing rare disease. GP's can't diagnose the cases properly, and the...

Slide at 8:56 in video - The Venn Diagram Result How this relates to ME/CFS. Without an ME/CFS clinic to pool patients from, the researcher has no access to the doctors who look after these patients to get a full clinical picture, and it is so much harder to get patients for a study. When...

Slide at 6:23 in video - The Researchers perspective

Slide at 5:33 in video - The Physician perspective

The presenter Dr. Laurel Crosby is part of Ron Davis's ME/CFS team at Stanford Genome Technology Center. I thought this video was particularly interesting as ME/CFS researchers share a lot of the same problems as researchers studying rare diseases. How to tie patients and doctors to...