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I've not read the paper, only the abstract. I find it really hard to believe that one drug affecting one receptor on one ion channel is the mechanism for improvement in responders to LDN. If you watched Alain Moreaus presentation at the recent OMF symposium you might remember he noticed...

Well done. It's the perfect letter. You are polite, recognise the good things they do, explain what concerns you, and offer a draft to replace the current text.

There are some patient stories on PR. It seems quite a few felt they developed neuropathy or thought their neuropathy got worse, despite taking B1 and ALA. So there is some significant risk...

There is an updated description of the study showing 3 visits over 3 years rather than just one visit, and patients must be diagnosed by a clinician according to the Canadian Consensus Criteria. from https://www.facebook.com/pg/MEAdvocacyNetworkAustralia/posts/ If you follow the link there is...

Some good news on the Emerge Facebook page - It looks like they have the healthy controls they need. And interestingly they are also performing a skin biopsy on the arm (as posted by @Andy above)...

@mariovitali DRP1 mentioned again in this paper. A quick search shows there seems to be quite a few papers showing change of DRP1 with Dichloroacetate

@mariovitali When I played with the tool I compared the actual dose with a "no-variants" dose. i.e. a dose where the reference allele was used. That method might provide you with a little more context..... then again I didn't see much difference so gave up........ I'm guessing that perhaps the...

@mariovitali To use the calculator to enter the variants this technical information pdf from the ARUP site is needed http://ltd.aruplab.com/Tests/Pdf/197

The first link gives a personalised dosing calculator that takes into effect the various mutations and from that gives you an adjusted dosing that you can use to take a guess how clinically significant they are in your own case. Calculator is rather difficult to use and if I remember right you...

@mariovitali Have you checked out this warfarin dosing calculator site. Some variants have a positive effect, and some negative. http://www.warfarindosing.org/Source/Home.aspx Some more info on the ARUP test site http://ltd.aruplab.com/tests/pub/3001541 Some more genetic pharmacogenic testing...

@mariovitali Have you come across any API's or tools to extract historical weather data from the internet? I'd love to track data because like you I've noticed a correlation but have no data to back it up.

If you believe their model then yes. But this is the raw data from actual measurements. Did they really only measure 2 hormones and model the rest based on their literature search???? Here is Supplementary figure 5. Here are some quotes from the paper on ACTUAL measurements :- Individual t...

This could be why some of them are linked - to do with blood pressure/blood vessel control https://en.wikipedia.org/wiki/Angiotensin Albumin seems related to electrolyte balance & water in blood control and also blood volume. https://en.wikipedia.org/wiki/Albumin...

Dr Leighton Barnden gave a talk at the Australian ME Conference on "Brain Stem Myelination & MRI Changes in ME/CFS" https://mecfsconference.org.au/videos/leightonbarnden/ I believe Dr. Van Elzakker's interest is also the brain stem. I'd be interested to hear how the two groups are similar and...

MEAction have uploaded 29 individual videos to their channel as well https://www.youtube.com/playlist?list=PLhO4nWkiP5QRt_Hjd4B-PWpKMlIJxXXrM

FYI - This paper is not paywalled now. For everyone's benefit this is a paper describing the exercise testing that Klimas has been doing in ME/CFS, taking blood at 8 timepoints, and measuring hormones and cytokines, and how they fitted a computer model to it. This is the one she has raved about...

Jarred Younger received a grant from the NIH for brain scans in ME. Is there an opportunity to coordinate work between the two groups so that together the field moves forward faster? e.g. something you find, or a technique you use, would allow him to test your small sample observation in a...

In 2018 Prof Theoharides came out with a paper titled "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis?" Thread here...

This is a similar question to one I wrote in the Karl Morten thread In his NZ presentation Karl Morten showed a 6 fold increase in Glutamate and a reduction in Glutamine. (finding not replicated yet) Here is his slide of data scatter In your Harvard talk you presented changes in Glutamate...

No, it is not a typo, and not another study. The link you provided :) has a little more info (relevant section pasted below) that explains "2014 Conference" refers to when and where the samples were collected. The link in the quote below does refer to the paper in this thread. It seems it took...