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I wonder where these 4 applications are in the process. Must be 5 months now. None appear in the NIH reporter tool :(. I wish the process was more transparent. Nine months have passed since this application Solve ME/CFS keep saying how important it is to have initial results from pilot...

The larger clinical trial he did had a sugar pill placebo arm https://clinicaltrials.gov/ct2/show/NCT00568555?term=low+dose+naltrexone&cond=Fibromyalgia&draw=2&rank=3 Here is the paper he wrote in that Fibromyalgia LDN study https://www.ncbi.nlm.nih.gov/pubmed/23359310

Agree. Also, I'd imagine that it is hard to do a blinded trial using LDN. Many people get disturbed sleep when starting, and have to ramp slowly. EDIT: In FM he did immune monitoring at baseline and at end that may interest some folks...

Younger did do two trials in Fibromylagia at Stanford using LDN https://clinicaltrials.gov/ct2/results?cond=Fibromyalgia&term=low+dose+naltrexone&cntry=&state=&city=&dist=&Search=Search and as I posted on the another thread earlier, there have been 40 clinical trials registered using Naltrexone...

Clinicaltrials site shows 40 trials on Nalterxone are registered (all diseases), with a subset of those with LDN...

There seems to be registry here for people who believe their neuropathy has a genetic component. https://neuropathycommons.org/content/join-neuropathy-gene-registry This paper found gene expression of MMP9 to be upregulated in patients. What might be of interest to you is the list of meds the...

I think it may also be important to map out what happens after the initial findings from this study appear. For example will there be a budget earmarked to follow up say the top 5 findings - e.g. take a small sample of blood from patients who have the variants highlighted and perform proteomics...

I guess the problem is that the population stratification of the control group needs to match that of the patient group. This was @Simon M comment on this thread covering a blog he wrote on the topic of a GWAS study in ME Researchers propose deep trawl of DNA to help uncover the causes of...

Makes me very happy to hear of pwME involvement so thanks @Andy and @Simon M One point I'd like to bring up is on the expansion of the UK ME/CFS Biobank as part of this project proposal. Two things stick in my mind * Ron Davis said a couple of years ago that they looked at using Biobank samples...

@Simon M @Chris Ponting You guys will be interested in this. The team are looking at rare CD4+CD8+ Tcells and quantifying the TCR repertoire of this unique population https://solvecfs.org/liisa-selin-and-anna-gil/

Very interesting link @mariovitali There are also papers stating mast cells produce NO as well as react to NO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900003 I wish I knew what Chris Armstrong was working on regarding Nitrogen

phenylalanine is definitely on my radar. Chris Armstrong was the first to highlight it. Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in Chronic Fatigue Syndrome patients...

I can only think that the original paper used < rather than > and that confused people reading it. e.g. they wrote G<A rather than the more usual A>G

https://www.ncbi.nlm.nih.gov/clinvar/variation/313386/ rs841 is very common - 22%. https://www.ncbi.nlm.nih.gov/snp/rs841 Clinvar has 3 citations stating benign. https://www.ncbi.nlm.nih.gov/clinvar/variation/313386/ I followed the link but don't see the scientific source for lower HRV and...

Okay, from GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease: Effects on Vascular Superoxide Production and Endothelial Function that you reference above I interpret this as 2% of study patients with all of the following has BH4 reduced by 80%...

@mariovitali I don't see much excitement on gnomAD Broad Institute database. No protein coding genes. Some variants have no transcripts...... Here are the links. Gene GCH1 rs4411417 https://gnomad.broadinstitute.org/variant/14-54853845-T-C?dataset=gnomad_r3 rs752688...

These are all very common Gene GCH1 rs4411417 Alleles T>C 22% (Reference>Variant) https://www.ncbi.nlm.nih.gov/snp/rs4411417 rs752688 Alleles C>T 22% https://www.ncbi.nlm.nih.gov/snp/rs752688 rs8007267 Alleles C>T 30% https://www.ncbi.nlm.nih.gov/snp/rs8007267 rs10483639 Alleles G>C 26%...

I'm really excited that Dr Karl Morten has been awarded 69K to build up a collaborative team at Oxford and specifically look at Mitochondria. I'm doing a happy dance in my head. One more comparison on the funding amount. Dr Paul Fisher is funded by the Mason foundation to investigate...

I thought the author information was interesting, detailing the CDC. I wonder what led to this paper being written....... Virtually nothing comes out of the CDC for ME despite significant funding.

There was an initial TRPM3 measurement study with 6 patients and 6 controls recruited and patch clamp measurements reported in August 2018 Paper : Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic...