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I agree that ME is a physical illness, but this reasoning has issues with it. ME from epidemics does not prove its an infectious disease, only raises it as a distinct probability. Its associated with infectious disease, and nearly certainly a consequence of infectious disease, but the disease...

Yeah, but it could be put down to stupidity or politics, not scientific misconduct. Its unlikely in my view, but its an out they may exploit. I regard objective outcome measures as mandatory for any study in which they are possible, except for small pilot studies. I suspect they got scared...

I regard the actometer issue as highly probable improper conduct, but it cannot be proven beyond any doubt. The improper conduct with SD and SF36-PF can be proven beyond ANY doubt.

The knowing improper calculation of "normal" for SF-36PF in the PACE trial is an example, though the currently preferred term is scientific misconduct. "Misconduct" downplays the harmful impact of doing this and helps preserve the image of the medical profession.

A.k.a. listen to Popper, and practice modern scientific methodology. Who would have thought this would be better than what is essentially verificationism, or the attempt to amass data to justify your unproven theories. I have not yet read the full paper, I might say more later.

To me this is the core of the problem. Lots of diagnoses in psychiatry have no objective basis. We know something is wrong, but we have no idea if the pigeonholes we want to plonk patients into have any basis in reality. They are all symptom clusters. Sadly CFS is in the same boat, and ME as...

That was my interpretation too. It sounds like genetic engineering of yeast to put our vulnerabilities in them. Being easy to grow you then have large samples to work with.

An expert is only more likely to be right. In science everything is provisional. Medicine is even more inexact, and long standing views get overturned from time to time. In fact many of the big successes in EBM have come from overturning views. The main problem with EBM, as I see it, is how the...

I have participated in a number of long debates on this. Its been a problem as far back as I can recall. Not having a diagnostic test is a huge impediment to credibility. Having conflicting and misleading diagnostic definitions does not help. The problem that most doctors do not read...

Beware bugs, ummm, sorry, special program features. The real issue is still interpretation. No psychiatric diagnosis is stable, as in proven to be a discreet clinical entity with reliable diagnosis, at least so far. What can be done with QEEG from my limited reading is determine likely cognitive...

QEEG findings have been reported on before, I regard it as an essential test that almost never gets done. The big reasons are its non-invasive, and can tell you a lot about cognitive function in one single test. QEEG and similar methods are routinely used in stroke and brain damage patients.

This rate of genetic problem in IDO2 for controls is much higher than previously reported, initially from population figures (not controls) a rate of more like 40% was reported. This can easily change how we view IDO2. The results still appear to be significant, but start looking more like a...

This fits a lot of the data, and is one of the things I think many researchers are considering. The miRNA and metabolomic data are both consistent with this, especially considering matches with African Sleeping Sickness and Sepsis. However its looking increasingly likely that some essential...

The most stupid part of most technological devices is the person running the machine.

I think the evidence strongly suggests its both a genetic predisposition and a virus or maybe many candidate viruses. Indeed this might mean its an otherwise unremarkable virus, and only those with the genetic risk have severe issues with it. 69 out of 70 with an IDO2 mutation is far too many...

The brain has the property, if I am recalling this correctly, of shutting down function under low energy. That might mean capacities are partially blocked. The brain does not necessarily decline in function evenly. Cheney was the first to discuss this in respect to ME in that we lose function in...

I looked into this years ago. In some states it was even legal to record a medical interview and not tell them you are doing it. You would have to check your current state laws. They might even have changed since I last looked so there is no point in me telling you what little I recall at this...

It took about 108 years after discovery of bacteria causing ulcers before Barry Marshall did his experiments. I was informed it was being discussed to suspend his medical licence because, presumably as I don't have details, he was considered a quack. In 2005 he shared the Nobel prize for the...

Yes, the metabolic trap model has issues but, pending publication, it looks like the genetic basis is so common in us that the chance of it occurring randomly in their study is one in about ten to the twelve or so. My math might be way off, could someone check it? I still don't have my math...

Yes. If its a fatigue model it has major problems.