Search results

If you take "mind" out of the discussion, and focus on brain, stimuli, brain changes, physiological changes, you can avoid the traps psychogenic thinkers leave in their muddled claims. I put the hypothesis out there, not for the first time, that all so-called psychogenic diseases are physical...

Not at all. Emotional and experiential events induce brain changes. Brain changes can lead to things including depression. Brains do react to stimuli, including internal stimuli. Nobody questions this. It is NOT the same as psychogenic disease. It is also not valid to claim that a disease is...

Having an uncurable chronic condition which can be highly debilitating, no useful medical support, scorn from family and support systems, that could in no way be depressing? I do think reactive depression is possible, and hard to treat in us because of how many of us react to SSRIs. We do not...

I have had an interest in this area for a long time, largely because of the cAMP/Ca++ axis, and resveratrol. One of the drugs under invesigation by RonDavis' group has a resveratrol version.

Yes.

Yes, but the highest concentration of oxidative stress as free radicals would be inside the mitochondria. Furthermore, these proteins are folded INSIDE the mitochondria, so that a lack of reduced glutathione, induced by oxidative stress, means a lack of folding. This is not the same as free...

Proper folding of proteins requires reduced glutathione. Oxidative stress or glutathione deficiency (including potentially cofactor depletion like lipoic acid) make this a big issue. I have been talking about possible misfolded mitochondrial proteins for decades now. The total amount of the...

So far as I am aware the creation of such cultures is a well established thing. I am unsure about brain cells though. Tissue cultures allow a lot more testing, but you do have the risk that the processes used to create them might introduce changes. It really depends on what you have done to...

Both regular medicine and alternative medicine have risks. Some forms of alternative medicine are just dangerous with no mitigating effects, just unfounded belief. Like laetrile.

Doctors have faced the death penalty, I think, for similarly dangerous practices (laetrile), at least in the USA.

The evidence is moderately strong that something in the blood is large molecule size, which might include vesicles, and mediates cellular energy deficit. It may or may not be the whole problem, but it must indeed be caused by something. As a possible mediating mechanism its a target for...

I suspect the nanoneedle test will NOT distinguish ME/CFS from mitochondrial disorders. However it may be that the existing diagnostic protocols, such as CCC or ICC, PLUS the nanoneedle test, might be enough.

Correct, but misleading. With a target that may be a mediating step for our energy loss we can develop new drugs, repurpose old ones like the SS drugs, and so on. Its something that is potentially treatable. While knowing the root cause may be very important for a cure, knowing mediating...

I would really like people with mitochondrial disorders to be tested. No salt response, full response, or mixed response would all tell us something. If the mixed response relates to specific mitochondrial disorders and not others it would tell us a lot.

Its the objective outcome in scientific studies that is indeed lacking. Its only been since about 2007 that this idea has started to be pursued. Let us be clear though, what we can scientifically prove for the disease entity Myalgic Encephalomyelitis, what we can clinically prove for...

They avoid this like the plague. EVERY study that uses objective outcomes for CBT/GET has failed, either showing no benefit or a decrease in capacity.

I think we have enough evidence now to be talking about the response to energy demand, not just exercise. This might also include immunological, emotional and cognitive energy demands. What seems to be lacking is what many call respiratory reserve, the capacity to ramp up aerobic energy...

LORETA software is used in quantitative EEG, which is confirmed in the article. It shows major abnormalities in ME according to the limited research done so far. Its very early days but it does need further study in my opinion. I am guessing this happened in this case. In combination with repeat...

One of the issues with calcium channel changes is changes to intracellular calcium. If there are any it might mess with the calcium-cyclic AMP balance, effectively causing an intracellular hormone shift that can profoundly change cell function, for better or ill, though more likely a mixture of...

I have not read the paper yet, but it seems to me that this paper may just raise questions, not provide answers. GWI also does not have a definitive test. Is it really ME in these patients? Or is PEM not unique to ME? Or do these patients have both ME and GWI? Or is there yet another explanation?