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  1. J

    Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World—mentions chronic fatigue

    “Ms. Bowman started taking BPC-157 and TB-500 last year hoping to address chronic fatigue, and said her sleep had improved right away. She logs her injections in the Peptide Tracker app, monitors her sleep and heart rate, and gets bloodwork done regularly.”
  2. J

    Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World—mentions chronic fatigue

    https://www.nytimes.com/2026/01/03/business/chinese-peptides-silicon-valley.html?unlocked_article_code=1.BlA.EnVI.FmgJ-R2kBu0h&smid=url-share Mentions chronic fatigue
  3. J

    Very Wealthy people’s charities — News, Advocacy Ideas etc.

    “ Today is World Autism Awareness Day. My wife and I want to raise awareness of and help decrease any stigma around autism by sharing that my wife learned she has autism later in life—in her late 30s. It’s common for girls and women to have autism overlooked due to their often subtler signs...
  4. J

    Feeling worse from oversleeping—poll

    How about this?— the sleep that you get from morning re-sleeping is less likely to be NREM sleep, so there is sleep but little or no clearance of junk (glymphatic clearance) which leads you to feel crappy—see here for example...
  5. J

    Feeling worse from oversleeping—poll

    Yes, this is what I was referring to initially.
  6. J

    What a longevity expert eats in a day—Eric Topol

    Posting because Eric Topol comes up frequently here. TLDR; nuts and salads https://wapo.st/4piAKUk
  7. J

    Feeling worse from oversleeping—poll

    Interesting. I’m usually ok with daytime naps. It’s going back to sleep in the morning that kills me.
  8. J

    Feeling worse from oversleeping—poll

    Here’s a Reddit thread from non ME/CFS people. “
  9. J

    Feeling worse from oversleeping—poll

    Good question! I don’t remember having anything like this when I was normal.
  10. J

    Feeling worse from oversleeping—poll

    I know this topic has been discussed before on here, but can’t find the thread. If you wake up early-ish and feel somewhat normal and then go back to sleep for an additional hour or two, do you feel worse after the additional sleep than you did when you initially woke up (like more tired/more...
  11. J

    Stimulant medications affect arousal and reward, not attention networks 2025 Kay et al

    Highlights • Stimulants altered functional connectivity in action regions consistent with arousal • Stimulants altered functional connectivity in salience regions consistent with reward • Stimulants did not affect canonical attention networks • Stimulants reversed the behavioral and brain...
  12. J

    Age-specific alterations of the gut mycobiome in patients with ME/CFS and identification of potential diagnostic biomarkers, 2025, Wei Guo et al

    Haven’t read but: All Chinese authors All Chinese institutions Not a review article No Traditional Chinese Medicine angle A shape of things to come?
  13. J

    Proxy Praxis: How Surrogate Endpoints Can Speed Drug Development

    “We treat clinical trials as pass/fail gates. That’s a mistake. Trials are a discovery engine. Clinic-in-the-loop describes how we use early in-human failures as data — exactly how CAR-Ts evolved from setbacks into curative cancer therapies.”
  14. J

    Proxy Praxis: How Surrogate Endpoints Can Speed Drug Development

    Another article https://press.asimov.com/articles/clinic-loop
  15. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I think I may have asked this question somewhere. But are there any immune mediated diseases where a treatment only works on one sex? Also the four or five ? patient Amendment may have included males—we don’t know.
  16. J

    Teclistamab for ME/CFS

    Did he measure total IgG before administering Tecli? NK cells?
  17. J

    News from the USA, United States of America

    "Dr. Koroshetz- head of NINDS/NIH - has always been respectful to me over the years. However, he never went to bat to address the absurdly low funding levels for ME/CFS. From that lens.. there is small chance that his replacement could be worse. Hopefully, it will be better."
  18. J

    Teclistamab for ME/CFS

    Everyone is going to hate me for saying this, but if Habets is going to administer Tecli, he should do normal multiple myeloma dosages, not these low dosages.
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