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T Cells, Aging, and Extreme Life Extension

Seems like Derya is a lot more interested in AI than ME/CFS research……Something about Newton teaching you physics.

If they said 20-25% you know they might be telling the truth. When I had plantar fasciitis the success rate of every single one of their likely bogus treatments was always like 60-70%.

Why is it always this number for all of these types of treatments?

Paul Graham retweeting Derya

Umm my primary care doctor bought one of these brain zapper machines for like $300,000. Last time I visited his office he was so excited to show off the zapper that he barely paid any attention to anything I said. He wanted a couple thousand dollars for like six zapping sessions. I passed.

Trump Will Slap Tariffs on Imported Drugs, Trucks and Household Furnishings https://www.nytimes.com/2025/09/25/business/economy/trump-tariffs-pharmaceuticals-furniture-trucks.html?unlocked_article_code=1.o08.c7FK.38aARxK1aLyi&smid=url-share

Are you going to open a tropical blueberry farm in Singapore to cash in? There actually are heat tolerant blueberry varieties. Maybe the real trick is mixing blueberries with durian and rambutan—could be the secret to unlocking sky high NK levels.

Actually agenda looks pretty decent—only a couple of sketchy things. Fluge is giving a portion of one of the presentations.

They could amend the protocol so the trial would last only 6 months. By 6 months you would know if it works. You wouldn’t have a good idea how long the remission lasts for. But you wouldn’t know that even if they ran the trial for 5 or 10 years.

Chat GPT says MM patients in active disease have low NK cells. I am guessing lots of injections are needed in MM because a lot of cells are tied up in various tumors. Active multiple myeloma: NK cell numbers often decrease compared to healthy people. Function is impaired: the NK cells that...

Any idea about this @leokitten?

Encouraging updates about the Norwegian daratumumab trial - - Trial is 80% funded, still fundraising for the remaining $500k- First participant will receive the drug next week! - 300 people have applied for the study's 66 spots

Also Fluge note that even with the high dara dosage protocols for Multiple myeloma, NK cells are not completely depleted. They also note in their article that for other autoimmune diseases there didn’t appear to be a relationship between effectiveness and the number of dara injections.

Just wanted to put this all in one spot: Subcutaneous Daratumumab injection schedules from Fluge’s group. Pilot group 1 Week 0,2,8,10 Pilot group 2 0,2,4,6,14,22,30 Amendment to pilot: 0, [10], 24, 48 (Week 10 only if no response) Phase 2 0,2,4,24,26 Based on what Fluge et al. wrote in...

Could you try to explain your point in a different way—not fully understanding. I do think that most of the “killing” occurs in the first few weeks.

Patients also recorded their perceived Function level in per cent according to a table with examples (Supplementary protocol). This one—don’t see it in the supp.

Hello, Can anyone point me to the function level questions that were used in this study? Thanks

Might be difficult—he seems to change institutions every couple of years.

He mentions patients were admitted to the Maes Clinics in Belgium. Is there such a thing @ME/CFS Science Blog ? Maes Clinics, Antwerp, Belgium. Google isn’t finding anything