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Probiotics may not do it, but apparently a good case of food poisoning can alter you microbiome... permanently. https://www.nationalgeographic.com/science/phenomena/2014/08/06/the-quantified-microbiome-self/ [I posted this article on another forum back in late 2016. ]

If you assume the range of values is 1 to 6 (as in the example), the odds of this happening by chance is 1 in 76.78244571, which doesn't really seem so suspect. It's the odds of rolling 10 dice and getting 5 of a kind. ETA: Corrected 1 in 66.65142857 to 1 in 76.78244571. This is for one...

Well, right about now, I'm wishing that my family had more severely questioned the "science" that said that margarine was healthier for you than butter. Based on those findings, my family dutifully switched to trans fat laden margarine in the early 1970's. Fortunately, the error was...

Wow, it's déjà vu all over again. By March 21, 2018, the SMC had a "fact sheet" out that said: By May 18th, after @Robert 1973 informed the CDC of the SMC's assertion that the CDC had bowed to pressure from patient associations, the SMC had quietly changed their fact sheet to read: Of...

I've read of lot of contemporary articles from the Los Angeles Times (and elsewhere) written during the 1934 LA epidemic. There were two types of prophylactic serum used in the outbreak - pooled serum from healthy adults and serum from convalescent polio patients. In both cases the idea was to...

According to Wikipedia... Calcium channel blockers are prescribed to treat hypertension for that reason. So, something else that interferes with the transport of calcium ions might also impair vasoconstriction - and vasoconstriction can be necessary to counteract orthostatic hypotension.

This current news article claims that there are 300,000 people in the US with Chagas and it is "spreading." However, I strongly suspect that the news article is irresponsibly leading people to believe Chagas transmission is rampant in the U.S. when it is not. This paper from 2011 says: So...

Well, for me, what you say did figure into my returning to work too quickly. I was trying to break into an industry via a job where I could easily be replaced and where being there every day was critical (it also didn't pay sick time, but that was not really the issue for me). It wasn't a...

Interesting concept of the "trigger." You could see this happening with some kind of infection coincident with a period of high stress (which pretty much describes my onset). Also, perhaps getting a bad infection during a time of stress makes it more likely that it will proceed to some kind of...

A great little bit comes near the end at 1:06:20, when they're talking about a response they got from Psychological Medicine suggesting that they should try to replicate the PACE study.

I wonder if this might have some bearing on the low ESR's (red blood cell sedimentation rates) sometimes reported in ME patients. The speed of RBC sedimentation is related, in part, to the red blood cells forming "stacks," which makes them heavier, leading them to fall faster in the...

My understanding of this [which might be horribly wrong...] When signaling in the brainstem becomes weaker, certain nerve fibers in the white matter carrying the signals become better insulated (with more myelin), so as to carry the weaker signals as fast as possible. This presumed compensation...

The idea of taking someone's allegiance for granted reminds me of this old joke (apparently originating in MAD Magazine in 1958)... Lone Ranger: "Look, Tonto, thousands of hostile Indian warriors coming right at us! How do we get out of this?" Tonto: "What do you mean "we," Kemosabe?"

BMC Neurol. 2005 Dec 1;5:22. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. Baraniuk JN1, Casado B, Maibach H, Clauw DJ, Pannell LK, Hess S S. http://www.biomedcentral.com/1471-2377/5/22 Anthony Komaroff summarized the findings of that paper before the Massachusetts...

There are a lot of variations on this, including, "I have not failed. I have just found 10,000 ways that won't work." It's unclear if he actually said this, though. During Edison's life, however, a colleague quoted him as responding to a question about a lack of results with,"‘Results!' Why...

Yes - and I'd go as far as to say that there is nothing that could ever lessen the esteem in which I -- how shall I say it? -- hold the Mayo.

Very encouraging. I'm a little surprised that they will only be taking a baseline and a 24-hour post-exercise blood sample. The Lights' exercise/gene expression test took a baseline and four other blood samples - at 30 mins, 8 hours, 24 hours and 48 hours, which allowed them to see a sort of...

Yes, it would be interesting to see the results if the patients had been told to answer the questions as they would have in the year before they got ME.