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I wonder if the "autonomic hypervigilance" could be compensating for some kind failure in breathing rhythm while asleep - sort of as an alternative to repeatedly waking and gasping for air.

Shorter is a (cross-appointed) "Professor of Psychiatry" at the University of Toronto. I imagine that many people see him identified as such (as in theconversation.com article ) and just assume that he must be a psychiatrist, or at least some kind of physician. But you know what they say happens...

Curious. The U.S. donation website at https://www.omf.ngo/triple-giving-tuesday-2019/ says: Could the minimum somehow only apply in Europe? ETA: It's not totally clear, but it looks like the minimum may apply if you want to use something called "Gift Aid" in the UK and are donating to OMF...

Interesting that at 16:22 in the Q&A video he mentions a site in the brainstem called the "nucleus ambiguus," which is apparently important in voluntary breathing (according to a "lesion study"). I know that myself and some others have mentioned the sensation of "having to remember to breath"...

I like the short list of symptoms they chose to display. It's very consistent with my experience, except for "chronic infections" (like many, I seemingly became "flu immune" after onset). "Unrefreshing sleep" has always seemed like a big understatement to me. What's a term for feeling worse...

I think he said that if they don't understand the disease well enough to cure it, they should also focus on prevention (as well as finding a biomarker, treatments and gaining a better understanding of the disease). If you have a cure, I suppose prevention isn't entirely necessary, although it...

I suspect that the follow up on this study faltered for lack of funding. Dr. Natelson was certainly making an effort to find funding to move on to the next phase. In that next phase they were going to test the most suspect of the unique proteins from the pooled results against all the...

So what is this application it wants me to download? Presumably safe?

Hmmm.... Googled "mirthful" and got this book from 2006...

This is a great article to have available on-line, particularly because of the association with the Harvard Medical School. It may not be news to the many of us who have been affected by ME/CFS for years and decades, but I'm sure it would have been incredibly helpful to have had something like...

I'd suspect that the connection between frequent colds and infections and the risk of ME/CFS is indirect; that is, there's probably not a shared "weakness" that results in both frequent cold/infections and ME/CFS, but rather that ME/CFS is often triggered by colds and infections. The more colds...

It's probably worth remembering that, between the trial and placebo groups combined, 70% of the patients did not respond (105 out of 151). 26% of those who received rituximab (20 of 77), and 35% of those who received placebo (26 of 74) responded, making the combined response rate 30%. I wonder...

I couldn't read all of this article. After the fourth reference to Shorter, my computer leapt from my desk and crashed to the floor to save me. It was a very loyal computer.

Longitudinal studies to capture and extensively test a large number of "high confidence" ME patients early in the disease and follow them. Some percentage of the patients will improve, some will got into remission, and some will feel they have "recovered." Compare their earlier results with...

When it comes to some of the BPS researchers and their allies, I think the problem is more one of an "unbalanced load."

The IOM report says: That does not really equate to 1/4 of all patients being bed- or house-bound concurrently. Likewise, Wikipedia's CFS page says: ...which does more suggest that the figure might approach 25%. Following the citation links on Wikipedia, I have not had much luck finding an...

They'll get the hang of it. Columbia's film school was ranked 5th in the country by the Hollywood Reporter. Maybe the Center for Solutions should try to enlist the help of some of their film students, if they haven't already.

Not surprisingly, the film, which was released in 2001, was called... "K-PAX." https://en.wikipedia.org/wiki/K-PAX_(film) :)

I tried to boil this down. I hope I got it right. POTS did not seem to predict whether a patient had disequilibrium. Disequilibrium (and signs which seem related to disequilibrium) were much more prevalent among patients who failed the 10 minute active standing test. Six patients who had...

“The man who has everything figured out is probably a fool. College examinations notwithstanding, it takes a very smart fella to say "I don't know the answer!” - Henry Drummond in "Inherit the Wind"