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This is an interesting analogy, especially if mitochondrial dysfunction is involved. At altitude, mitochondria presumably make less energy due to a lower concentration of oxygen. In mitochondrial dysfunction, however, they can't make enough energy despite the presence of sufficient oxygen - but...

A few months after onset, I had what seemed like one long, continuous migraine that went on for months. Sometimes it was worse than others, but the only real escape was during sleep. Nothing seemed to help, and, by that point, I had given up on mentioning new symptoms to doctors. I'm pretty...

A 2015 article in Scientific American about TMS and other "electro-cures." https://blogs.scientificamerican.com/cross-check/return-of-electro-cures-symptom-of-psychiatry-s-crisis/ The only one with good evidence of effectiveness (in 2015, at least) was electroconvulsive therapy (ECT) for severe...

Another reason why the numbers go up up with age might be that, in the US at least, children up to age 11 or 12, though they may attend schools with hundreds of other students, generally have little interaction with anyone outside of their classroom of 20~30 students. Once they hit middle...

Also kind of Orwellian (or at least ironic) is that, in Latin, PACE means "with peace." It's usually used as an expression of deference to a respected person's contrary opinion, sort of like starting a sentence with "No offense..." So... "Pace Mike, but I think this study* is for the birds."...

Can you really be engaged in a strategy to conserve energy while at the same increasing the amount of energy you expend? I feel like a law of thermodynamics is being violated here.

Yeah - oddly, I only started to have night sweats after the initial fever and sore throat had passed. I don't think I'd ever experienced that before. People can break out into a sweat when a fever breaks, but I assume it's pretty much a one time thing reflecting the system's realization that the...

If an infection was linked to one's onset, an interesting question might be how severe it seemed compared to other infections you'd had in the past. Mine was among the worst I'd ever had, but there had been prior infections of similar intensity that obviously didn't result in ME. The sore throat...

In Laura Hillenbrand's award winning article of her experience with ME/CFS, when she finally saw a doctor about her symptoms, she tested positive for strep throat (a bacterial infection, not a virus). She tested positive for strep a couple of more times, and, when she was later tested for EBV...

FWIW, the article was published in the... Journal of Psychosomatic Research Official Journal of the European Association of Psychosomatic Medicine

Yeah, I'm not sure how you can tell if a "patient's cognitive and emotional concepts" of their dizziness and vertigo are inappropriately impacting their degree of handicap - unless you had experienced similar symptoms over a similar duration - and how would you know if the severity of symptoms...

Perhaps I'm misunderstanding this, but it almost sounds like they're suggesting that if patients would only "lighten up" about consequences of dizziness and vertigo then they wouldn't be so handicapped. I'm perfectly willing to let any interested investigators test this theory by riding along...

I'm surprised it's as high as 83%. It was only several years after onset that I first noticed PEM - by which I mean feeling oddly worse the day after exertion. It took me a long time to make that connection because it's so non-intuitive. I was only able to distinguish PEM after my background...

There are occasional outbreaks of Hepatitis A that are traced back to restaurants. It seems to follow the fecal-oral route. In other words, someone is not paying attention to the "All Employees Must Wash Their Hands" sign. Other diseases, like polio, have the same mode of transmission.

Jason is a professor of psychology - and he was diagnosed with CFS in 1990 - so perhaps including the psychological angle was important to getting support from the psychology department of which he is a part. As @rvallee said, seeking psychological risk factors may well be just a way to...

There is a thing where, if there is a source of "white noise" present, like a fan, or wind, or rain or a radio tuned to static, the brain can perceive the white noise as indistinct music or voices. I've experienced this on a few rare occasions in the presence of white noise, but the vast...

At one point he says that ME/CFS is: 2x as common as epilepsy 3x as common as Parkinson's disease 4x as common as MS 40x as common as motor neuron disease (aka ALS, "Lou Gehrig's Disease") ...which are pretty interesting statistics that I've not really heard presented all at once before.

I wonder if they consider the possibility of exercise-induced bronchoconstriction as a possible cause of hyperventilation. I say this because I've experienced this since childhood and only recently discovered what it was. I've had several treadmill tests over the years and no doctor has ever...

Well, that takes a load off my mind.

Interesting that his onset followed strep throat. I suspect my onset also followed strep. I (foolishly) didn't see a doctor about it, but it was unlike any sore throat I'd ever had. Every time I swallowed, the back of my throat felt like I was drinking acid. Those sore throat lozenges were...