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If I could go back and change the course of history I would stop Covid and LC from ever happening. On the other hand, it has probably been a serious boost for progress on ME, both technical and ethical. So there's that silver lining.

Cargo cult.

One thing that gives me hope is that a paradigm change is rarely a gradual smooth linear thing. The situation looks more or less static for a long time, then a critical mass is reached and over a (relatively) short period the whole situation changes. With a bit of luck, the sort of thing that...

To develop better quality evidence about T&CMs for CFS, future studies should employ more objective diagnosis standards and outcome measurements, larger sample size, and better bias control, and ensure the compliance with the corresponding reporting guidelines. That is how it is done.

Yeah, interesting how the psychosocial crowd only seem to worry about iatrogenic danger with biomedical explanations, never with the psychosocial ones. There is definitely a big psychosocial component to our problems, but it is with how we are viewed and treated by the advocates of psychosocial...

might be an association Does this even justify further research? :bored:

When accusation becomes confession.

I am a strong supporter of free speech. But my hard earned cynicism says that what at least some of the signatories really want is the right to lie and defame with impunity, which is not a right I support in any form. Even the USA recognises that free speech is not an absolute right, that it...

I don't know if ME can exist without PEM. I do know that it is such a common feature of ME, and a distinct phenomenon in its own right, that it must be controlled for in any studies and assessments.

whereas the ratings, algorithm, signalling questions and guidance built into the RoB 2 tool made it easier to work through complexity and context. So, more wriggle and less rigour? (EDIT: Not suggesting that complexity and context don't matter.)

Can't access the full article, but I hope they used a dummy filter arm as well. That would provide a clear answer either way.

Exactly.

This is exactly what is going to happen. We know this because it has historically happened. Only now it will happen on a vastly greater scale.

Furthermore, it may seem that it makes little to no difference what type of face mask is used. That is a pretty big red flag about the review quality, IMHO.

'Promising', and always will be.

Arguably best to tick every formal admin box along the way, so they can't say you didn't try it. One of the most powerful tools we have is going through all the formal processes, and getting the important stuff on the formal record. Then nobody can say they were not informed.

Creating a[nother] “Brain-Mind-Body Interface Disorders” Diagnostic Category Across Specialties The less they understand what they are dealing with, the more frequently they invent new names for it. It is their substitute for progress.

No improvement was established in patient's level of functioning. Psychosomatic therapy could be an important treatment to improve PSS management. Those two statements do not fit together. Some patients may need more explicit attention to a shared biopsychosocial disease model, more focus on...

If it was the structure then the weakness would not transiently improve, the tremor would not transiently stop, and the gait would not improve. One hell of an assumption/assertion. Neuroscientifically, structure-function relationships are closely coupled, suggesting that functional disorders...