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  1. Sean

    Advice on mask-wearing to protect against Covid-19

    Yes, important to keep in mind that is the minimum standard they have to meet – removing at least 95% of the target range of particles. They will typically do a lot better than that.
  2. Sean

    Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease, 2024, Khalid A. Hanafy

    1. The dominant paradigm has, until recently, been the psychosomatic one. 2. In no small part due to 1, the post-infectious hypothesis has still not been adequately researched. 3. The emergence of Long-Covid seems to me a pretty good piece of evidence that this is post-infectious. Not...
  3. Sean

    Advice on mask-wearing to protect against Covid-19

    I view masking up probabilistically. The right kind of mask, used properly, greatly decreases the risk of inhaling virus, and the quantity of virus inhaled if you are exposed. Particularly effective if your risk is casual, like mine. Meaning I am not in contact with the public much, so masking...
  4. Sean

    A biopsychosocial approach to persistent post-COVID-19 fatigue and cognitive complaints: ... 2024 Klinkhammer et al

    The game here is to flood the literature with apparently independent studies, all 'reproducing' the same basic result, using the same suite of flawed assumptions and methodology (mainly inadequate control of open label self-report measures, but also cherry picking evidence, selective...
  5. Sean

    1/18/2024 US Senate hearing on Long Covid of the HELP (Health, Labor, Education & Pensions) committee

    Also worth noting that, as I understand US politics, health research has long been one of the most bipartisan issues in Congress. If there is one thing the two main parties are more likely to agree than not it is this one.
  6. Sean

    Earseeds, Acuseeds

    She was once told by doctors that she would never work again or have children. Want some hard evidence for that. If anything in the UK she was most likely told that she just needed some CBT and GET, and that recovery was possible, with the right attitude, of course.
  7. Sean

    A Review of BMJ Best Practice Document on Chronic Fatigue Syndrome by Professor James Baraniuk

    Although previous randomised controlled trials (RCTs) have reported benefits to structured GET in the management of ME/CFS,... If anything, the body of studies on GET from the psycho-behavioural club are characterised by their persistent lack of adequate control. They have also not reported...
  8. Sean

    Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis, 2024, Maas genannt Bermpohl et al.

    Methods Randomized controlled trials... Stopped there. Anybody who can describe the body of psycho-behavioural studies for CFS as controlled really hasn't grasped the concept of control.
  9. Sean

    A Review of BMJ Best Practice Document on Chronic Fatigue Syndrome by Professor James Baraniuk

    Documents like this really should not be behind a paywall.
  10. Sean

    A general thread on the PACE trial!

    One justification given by the PACE investigators, and also separately by Wessely, for the changes was that it made the results consistent with those from both the previous trials and their 'clinical experience', and that otherwise no PACE patient would be classed as improved, let alone...
  11. Sean

    Employee well-being outcomes from individual-level mental health interventions: Cross-sectional evidence from the United Kingdom, 2024, William J. Fle

    Results show that those who participate in individual‐level interventions have the same levels of mental well‐being as those who do not In other words, a null result. The intervention does not work.
  12. Sean

    A general thread on the PACE trial!

    The lack of support from objective measures. No difference at 2.5 year follow up.
  13. Sean

    Review Impact of aerobic and resistance training on fatigue, quality of life, and physical activity in prostate cancer patients 2024 Nader et al

    although it has a limited impact on fatigue and physical activity levels. No impact, according to the abstract. These findings advocate a shift in clinical practice and positioning exercise as a core component of comprehensive cancer care. Tailoring exercise regimens according to individual...
  14. Sean

    Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naÏve individuals with Long COVID, 2024, Iwasaki et al

    I first learned the term 4 years into it, and it was a real shock of recognition, light bulb turning on moment.
  15. Sean

    USA: Massachusetts ME/CFS & FM Association news

    They are told that they are suffering from stress; that they are depressed or anxious. The implication is that their condition is psychosomatic; meaning that their emotions are manifesting as physical symptoms. This is a very invalidating experience that adds insult to injury. It is a lot worse...
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