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Here's an awful opinion piece about the possible use of GET in LC. I can't possibly comprehend what compelled this person to lead in with the militant ME patient narrative, without providing the reader with the necessary nuance to contextualize these accusations. It just leaves the reader primed...

The article is shockingly poor, but this little piece of research linked caught my eye: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105457/pdf/SHORTS-11-016.pdf I'm glad that the Lightning Process used to be seen as the phony CAM treatment it is. A shame that we forgot all about that, now...

>Finally, because of the purely explorative approach, P values were not corrected for multiple testing, resulting in a less stringent statistical analysis. I'm sorry, but could someone better versed in medical statistics explain why this is OK to omit in exploratory research? Why even bother...

"Let's run a survey on pandemic burnout and add some questions about long COVID to make it look more relevant."

Now, now. We aren't going to prevent people from changing their beliefs in the face of better evidence and experience, are we? Nah just kidding. It's not every day that you get such a salient example of how much people's opinions are usually based on their own preconceptions. And just because...

This person is likely using "somatic" as shorthand for SSD, but I find it funnier to believe that they actually don't know what their own terminology means.

"In contrast, we know that graded exercise therapy is an effective treatment for chronic fatigue syndrome (or ME), a clearly related condition. Moreover, no trials of graded exercise have shown harm to patients." Hey guys, the science is settled, didn't you hear? Stop discussing this issue...

>Finally, the study was designed to determine which biopsychosocial factors are associated with fatigue, but was not designed to identify causal relationships between the biopsychosocial factors and fatigue. I can't quite put my finger on it, but I'm confident that the increased pressure at...

I was making a point in favour of demarcating clinical constructs in absence of understood pathology via the clinical picture, but I also believe that inferring a *hypothetical* pathology from the same examination is ass-backwards. I didn't claim that it doesn't. I brought up the serotonin...

To be fair, this is the precise criticism I see medics make of ME *constantly.* Difference is, they don't know that ME has a distinct (generally postviral) aetiology, symptomology, and trajectory, and we do not make any claims of identifying any underlying disease process with our clinical...

Like clockwork. Leave it to Robert Howard to demonstate his utter hypocrisy and resistance to learning whenever one of his cronies grants him a fit occasion.

You must be referring to this study? https://pubmed.ncbi.nlm.nih.gov/25640602/ So what he did was to take a group of 120 adolescents diagnosed with ME via Oxford criteria, found that a substantial amount of those did not fulfill CCC, figured that the two groups do not differ with respect to a...

Would anyone kindly refer me to this evidence that concluded the noninferiority of the Oxford criteria? Because all I find are studies stating the contrary. https://journals.sagepub.com/doi/10.1177/1359105317695803...

Oh God, that's awful. I do find it telling that it's always physicians who file these sorts of complaints, and never the patients themselves. That said, an ubiquitous supplement was never going to be the key to curing ME, and it's a shame that things went downhill over a treatment that will be...

Decent article, although the words neuropsychiatry and rehab medicine trigger a visceral response in me. The authors have all been involved in biomedical research for ME, however. I hadn't heard of Gottfries and his weird origin story until now. The article is a bit on the nose about the fact...

This is some galaxy brain logic, considering that even in developed countries where ME is more commonly thematized, diagnosis is completely bottlenecked by lack of GP and specialist education. It's hard to diagnose a condition if you do not even have the words to operationalize it. I would like...

As an aside, is there any reason whatsoever to believe that clinical presentation and prevalence of ME differ between cultural and geographical delineations? Because this reminds me of this report on ME by the German equivalent of the CDC (RKI), stating that prevalence of ME is 11x higher in...

Yes. My first thought was that they were grossly neglecting the possibility of perpetuating factors, such as secondary gains. Must be nice getting to laze in bed all day without having to pull 80 hour weeks, after all. Furthermore, patient group membership has been shown to perpetuate illness...

What I also found funny is how the statement that GRADE's emphasis is supposedly on "what is most important to patients", is juxtaposed by the argument that the NICE committee is overly influenced by the patient side, via "theoretical arguments and anecdote." The bitter irony aside, the complete...

I'm curious, is there any reason for concern that the cited 2020 Moustgaard study could still end up having a negative effect on the evidence review process for the final version of the guidelines? Obviously, the lack of blinding was a major factor regarding the downgrade in quality of...