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Why would you need to show each datapoint on a one-axis graph? Showing the point doesn’t add any information that can’t be extracted from a histogram, and the histogram has the added benefit of showing the distribution of values. I guess they could make a stacked dot histogram (imagine this...

It always makes me chuckle to spot drawings of gear trains that won’t turn, at least if the outer gears are supposed to interact.

In both cases, the effect was larger for the 80 % most inactive than for the 20 % most inactive. How is that possible? Wouldn’t it be expected that the benefit of increased activity would be greater for those that are the least active, so you’d see a diminishing return? One explanation might be...

Overall they make many good points and this is far beyond what 99 % of studies do, but they seem to still have some blind spots. We’ve been complaining about inappropriate interpretations of questionnaires for a while. I think they could have gone further and said outright that PROMS can’t...

I’ve had similar experiences and I’m not under the illusion that being a «perfect» patient will guarantee better treatment. And doctors should be able to navigate that and ask relevant questions if the patients don’t give them the info they need. After all, it’s their job. But I do think our...

That’s understandable, but it can’t include gathering data from participants. At most, doing a preliminary survey to gather comtact info from people that might be interested in being contacted for participating later might be allowed, but I’m not sure of the specifics here. If the supervisor...

So they have already assessed all possible treatments and determined that none of them warrant a trial? Why not assess each application based on its merits instead of limiting it like this.

The eagerness to get started is understandable and it’s the uni that’s responsible for enabling the students to do things right, but here are a few things to consider before gathering data: Which data do you actually need? What are the implications of opening for sending you the whole genome...

There are a lot of them, and they usually posit that psychosocial factors influence the body in various ways and that that makes you ill somehow. The how is never clear to me, and the solution is always to think and behave differently.

I couldn’t find it when looking for it. Thanks for pointing it out. I’m sure UK privacy laws also cover genetic information.

They say you can send them their entire genetic file if participants can’t find the genes themselves. There’s some info, but I couldn’t find anything about secure storage, upper limit for how long it will be kept if the project stretches out in time. Or steps taken to ensure anonymity. Even...

Thank you for elaborating. You don’t have to share more personal info than you’re comfortable with, which might be none at all. Edit: I’ve removed a badly worded and not suitable question. Does that mean that you have to apply for approval? Who would evaluate the application? From your...

Oh, absolutely. I might have misunderstood earlier. I would only describe my symptoms in layman terms (even for the ones I know the medical terms for) - that’s usually all they ask for anyways.

Hi and welcome! What’s the basis for this belief? As you say it is very vague, and it reminds me like what the BPS proponents talk about with regards to functional disorders, bodily distress, persistent symptoms etc. Sidenote: do you have ethical approval for this research project?

Is that the problem, though? That seems to be more an issue with every paper being hyped as exciting based on what the authors claim themselves. So the truly exciting ones drown. I don’t think the name of the symptoms matter. If you want to call it OI or PT/OT/POT or feeling unwell when...

I don’t see any other reason for prescribing beta-blockers as treatments for POTS in general. If it’s believed that blood pooling is an issue - how does it make sense that lowering the HR would improve the situation?

If practitioners are providing all kinds of unevidenced statements about pathology and prescribing treatments without any evidence of safety or efficacy, it is not serious medicine or science. I think that qualifies as quackery, like how BPS is quackery. It can still be quackery even if it’s...

There is no assessment of the blinding. They also did not blind the people involved in the study. CFQ-11: The R group has a reduction of 7.2 points. The placebo group had a reduction of 3 points. The between group difference is 4.2 points, and the MCID is usually about 3-4 points. With what...

Surely the definition of gaslighting has to include something about the professional being wrong? And objectively measurable signs can also be dismissed on the wrong reasons.

NEGR1 is also familiar.