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To be clear CAR-T is not "just like rituximab", although it could be fair to say its approach would be similar. Rituximab is a crap drug in autoimmunity, weak and there have been many failed trials for diseases such as sjorgens, https://pubmed.ncbi.nlm.nih.gov/27431352/ ,lupus...

I know a patient who has significantly disabled with Long COVID, and for a while was focused on MAID. Awful situation. She is lucky and has wealthy family, she got CAR-T in a private clinic and is now in remission. I think its clear there is a sub-set of patients with ME and LC that have some...

im sceptical as well and would say im sure the norwegians are trialing dara for a reason and the reason is that ritux didnt work out of interest though why is it that you think the hard core chemo worked in some patients for the norwegian trial if its not something to do with antibodies and the...

Hi all, its appears a German Dr, Dr Habets who is an Oncologist, is undertaking a trial (or just randomly treating its very hard to tell) with Rituximab in Long COVID and Me/cfs patients who test positive for GCPR aabs via bioassay (ie not ELISA). Its REALLY hard to fully understand what is...

also yes to the CD20 b cell, fluge is on to something hopefully and i hope we get a blinded placebo phase 2 with his dara because i really dont want to have to do full chemo

Before i start i should say i do find t cell findings very interesting as well, if targeted therapies come out for that i would be intrigued to see effect (reduced list for brevity) Ok to keep it simple the b cell stuff and aab stuff i have found to be good/high quality is both theory and...

this doesnt seem to reflect the experiences of the patient who had me after mono for 14 years? what is a latent cancer, how if it was latent could it cause extreme me/cfs like she had? its like when people speak about HIV patients, they usually have 0 issues prior to AIDS - i worked in the...

im out at the moment, will find my list when i get home in a few days - plz nudge if i forget

I will go tell my neurologist who is running a trial for stem cells in MS that he is wrong then haha

You just linked the Iwasaki study that literally says: A number of significant changes in circulating leukocytes, including increases in non-classical monocytes, activated B cells, double-negative B cells, exhausted T cells, and IL-4/IL-6 secreting CD4 T cells, and decreases in conventional DC1...

Maybe they are checking ANA but im guessing they didnt present it as data as its not meaningful, i dont see why you are fixated on just ANA? Regardless we wont know until study is published. Come to think of it I believe they did this study after than awful chemo drug, saying it showed moderate...

What i mean is in their trial they are not using ANA to diagnose ME/CFS and treat patients in this trial, because its not commonly associated with post viral disease, its not seen in long covid either but massive b cell activity is...... I dont think they are using the celltrend AABs but...

the norwegian team arent using ANA so i dont feel thats relevant. we know it didnt work for everyone, we know its safer than ritux, I can only hope we get a better phase 3 as rituxs phase 2 were so good then, well we all know what happened.