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Hi all Ive just been reading about Rituximab within the context of autoimmune disease. Im aware of the CD20 and plasma (antibody generating) split within cells, but that for a lot of autoimmune diseases there is clinical response and patient symptom relief. We all know about the failed Ritux...

you mean doses are around 6-800mg per m2 over 6 infusions? Do you mean the specific Lupus low dose type stuff: https://www.jrheum.org/content/jrheum/49/6/607.full.pdf thats a bit different, The EuroLupus regimen consists of a fixed dose of CYC (500 mg) administered every 2 weeks for a total of...

sorry just on that note of alemtuzmab toxicity/implcations https://academic.oup.com/brain/article/145/5/1711/6590581 Alemtuzumab is a monoclonal antibody that causes rapid depletion of CD52-expressing immune cells. It has proven to be highly efficacious in active relapsing–remitting multiple...

exactly with all due respect JE and i do mean this as having the weight of a drug toxicity that can cause a horrific deadly cancer is not a light thing for a clinician and i understand and do respect this, i just think there is no alternative at the moment. I am not sure about campath1 but i...

If your own clinic had a 20% rate I can at least understand this level of conservativsm. Studies, an the information I was given, show in general a much more complex picture than this figure and was presented to me as a issue of accumulative dose and a non negligible but low risk and this was...

well apparently we should just do nothing risky because we are too difficult a population group, I understand being conservative and risk adverse but apparently it doesnt matter that ME and LC patients are at risk of suicide because the quality of life is atrocious

why is further evidence not required? because of the risk? in a patient population where suicide is a HUGE risk? https://www.tandfonline.com/doi/abs/10.1080/07481187.2020.1776789 . Its very dispiriting to hear a medical professional say no to more information that could help patients, that does...

ok 1) No one is calling for high dose, life threatening cylco AT ALL. Thats HSCT which is insanely controlled in an ICU and still has a 1% death rate. It seems effective for MS yes, more data needed as per ususal = https://www.neurology.org/doi/abs/10.1212/WNL.0b013e318211c537...

they note here that the cyclo remission/effect group correlted with IgG and IgM reductions but that didnt hapen in ritux even though the IgG dipped. The anaylsis is good and is why i myself have started cyclo recently cos i think its possible that this is a novel autoimmune type disease we wont...

gosh these authors like to jump out with their theories dont they

i appreciate this is your, an quite a few good peoples onset experience. i have to say mine is totally different, one day fine after about a week post acute covid recovery, the next day completey bedridden with severe ME/CFS long covid

i bailed on this to do cylco due to my concerns with the limited data, sorry gang

IIRC fc receptors are also on other immune cells such as macropahges and dendritic cells, i am expecting this to go to phase 3 but it will be unlikely it will prove the aab theory

yes sadly i would say that ME might even be used as a text book example in the far distant future of just how difficult it is to work out the EXACT nature of an "immune system" disease that is not clearly or purely autoantibody driven, nor pure innate immune system driven using current...

i dont know much about the t cell theories but a lot of it is newish i think that t regs are supposed to be an inbuilt mechanism to help stop autoimmunity no?

i think the theory is Pd-1 receptors are found more in t cells that are used by t-regs to limit immune activation and try and prevent self-attacks on cells/tissues etc. There is also associated molecules that i dont understand, nor do i know how they tested for but they did not in this paper...

well said, as someone with a background working with the CLEAR immune dysfunction that is CAUSED by HIV (i worked in S. Africa with clinicians but not a clinician or med worker), this is maddening to see. 0 evidence of dormant or reactivated viruses here and also terrible terrible work done in...

hard agree, at worse these drugs also CAUSE autoimminity in rare cases. This is a potential disaster

on medication im very much able to weight lift and ive become quite strong over the last year tell someone who can lift 25kg+ as a smaller woman that they are deconditioned when most lift <20kg lol

in all honesty im not sure if there is much spontaneous ME remission, and im certainly not holding out for it there ARE very good placebo trails ongoing thats what im saying, just not by the NIH lol