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@jnmaciuch check out the following thread reply on X/Twitter which may be of interest regarding ubiquitin ligase :

OK makes sense. If you have any set of genes that appear to be important please tag me so I can have a look at them.

OK, I began by taking the first set of genes s1 by following this link : https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GOCC_SWI_SNF_COMPLEX and clicked on the "(show 30 source identifiers mapped to 30 genes)". This is the first set of genes, which were extracted. Then I did the same for...

So I did some preprocessing to extract all genes from the links @forestglip gave, identify which genes are duplicated and feeded them to the information retrieval system I have been using. The results -from my Information Retrieval system- show that we are looking at the following concepts ...

@Murph Thank you for this article. There is a study which just came to my attention. Title : Generalization bias in large language model summarization of scientific research which can be found here : https://royalsocietypublishing.org/doi/epdf/10.1098/rsos.241776 The paper suggests that...

Here is the answer regarding similarities between neural function and spermatozoa using a mixture of agents approach. Reliance on membrane excitability appears to be important :

@Snow Leopard @jnmaciuch @Jonathan Edwards , please have a look below. @Hutan @Simon M you may be interested as well. Reasoning Engine is o3 . Note that the engine found the upcoming study by the Austrian University (...) : and and finally : EDIT : The part where it writes...

Sure, totally understand but I did not ask you about glycosylation itself. My question is : despite all research being done, are we sure that glycosylation works as expected in ME/CFS patients? Maybe again, this is a vague question so I will try to be more specific. Please have a look at the...

Sorry, but I do not understand why this is so. Practically speaking, if a number of analytical methods can better analyse and interpet existing knowledge, isn't this information that can potentially help us improve patient lives ? AI is now being used to optimise the function of ER departments...

Some comments regarding previous posts : 1. I believe that AI can understand and identify whether a study's design is a proper one and identify any wrong doings quite easily now. So we can train an LLM to spot these wrong doings and have it report them to us. Example from this forum ...

@Utsikt I hoped that my examples would be obvious for you, clearly there weren't given your replies. It would be great if anyone else would like to comment so we have other opinions.

(1) "If the data doesn’t contain the interaction" - This is an assumption. How do you know it doesn't ? (2) "AI will never find it because AI can’t create information" - In other contexts AI does create information but we will talk about medical science here. (3) "In your example you already...

This work should be further investigated in my opinion and see whether ME patients have LCAT dysfunction. From the paper, observe the mentions on PGC-1a , ABCA1 and LXR : The author also mentions "Reverse Cholesterol Transport" and Choline deficiency (Phosphatidylcholine) : Here is the -now...

@Utsikt regarding the following : What AI can do is to better connect the knowledge we already have, better than any human. As an example, Telcos wish to find subscribers that have a lot of social connections. If I give to you or any other human the Call Detail Records (CDRs) of thousands of...

Which conditions are considered proxies to ME/CFS ? Fibromyalgia for example?

Dear All, I would like to provide details about the existence of a new reasoning framework, available for ME/CFS research. In this post I will give a brief description and a post will follow with the hypotheses that have been generated. This framework uses a number of Large Language Models...

I submitted the genes listed earlier by @Jonathan Edwards to the framework I have been using. Below are results from one ranking method pointing mainly to DNA methylation and phosphorylation. Of interest, liver comes up again along with glycoproteins and lipid metabolism. Note also insulin and...

Sorry, for the double post I couldn't edit the post above. Here is the response from a mixture of AI agents on the subject. The potential use of piperaciline is mentioned (which is discussed in the StatNews article linked above)

Below are AI-assisted suggested ways to clear persistent peptidoglycans. @Jonathan Edwards would you like to comment ? I also asked whether UDCA can be used for this purpose. https://chatgpt.com/share/6809de33-95e0-8006-8c2a-1a0de437130c

Fereshteh Jahaniani with PhD in pharmacology wishes to explore the connections between fluoroquinolones and mitochondrial damage :