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Hoping this helps in any way :

Thank you for your reply. Actually the responses are not included in my message (=the hypotheses) . One hypothesis text for example states the following :

I am sharing the initial results from the analysis I have been performing using 5 different reasoning engines to suggest causal hypotheses given the GWAS results and the candidate genes. @Hutan it was difficult to extract text because of the table. I will not provide the details on how it was...

May I also add that hemochromatosis negatively affects the liver. I made numerous posts here regarding this connection (and hemochromatosis was mentioned in my presentation at EUROMENE) https://www.s4me.info/threads/machine-learning-assisted-research-on-me-cfs.5015/#post-90319

Good question. A second layer of data with lower confidence from GWAS were the results in certain lipids (e.g. cholines) being low in several studies. A third layer is comorbidities and so on

I just used ChatGPT5 with an entirely new approach in my prompts and I am posting the results here. This means that the LLM is presented with the most solid evidence (e.g. GWAS results) and then layers of information are given in subsequent prompts as newly added knowledge (e.g. metabolomic...

Liver disease, again

I agree with @Murph but just to say that N-Linked glycosylation can also lead to ER Stress (and N-Linked glycosylation has a direct effect on ER Stress as opposed to O-Linked glycosylation). I wonder if these researchers looked at N-Linked glycosylation as well or if they are planning to. I...

@Utsikt I don't understand your reply to be honest. In case you believe mecfs is strictly of viral origin then you should reconsider by looking at the known triggers

Or perhaps also metabolic hits such as environmental toxins and even certain medications

Now published : https://www.mdpi.com/1422-0067/26/13/6082

I strongly believe that OCD, ADHD, depression, anxiety disorders and several other psychiatric disorders are related to mitochondrial function and impaired metabolism.

So I did a second run using my favorite method which is submitting the same input to a number of reasoning AI engines. This time the prompt was even more generalised. Prompt : Here are some parts from the answers of the three different reasoning Engines : Engine 1 Engine 2 Engine 3...

I agree but I didn't provide any information. The session was totally new. I am very much inclined to submit findings of another study with proteomic results using the same prompt and see what i get. I believe that a word which may have biased results is "exercise"

Some comments regarding this study. It mentions ER Stress and protein folding as potentially important. I would also like to point to your attention the mention on PDIs (Protein Disulfide Isomerase). For readers who are aware of my work, ER Stress, Protein folding and Autophagy was one of the...

Just realised that among the downregulated proteins is IFI16, which is Gamma-interferon-inducible protein Ifi-16. Not sure if this is relevant to the theory of @Jonathan Edwards so making sure this is noted. https://en.wikipedia.org/wiki/IFI16

Thanks @Hutan I found an association of neopterin with IDO1 (indoleamine) https://www.degruyterbrill.com/document/doi/10.1515/pterid-2013-0037/html?srsltid=AfmBOorch-SC9s8Y_k9TDgWWzal-tQXPpda0XrdEKLQTQSCUo2biQDBg

@Jonathan Edwards I submitted to the analytical framework I have been using the FcRi receptors mentioned, namely CD64, CD32, CD16 in order to identify any associations of interest. The framework suggested an association of these receptors with MERTK, among others. So i searched and found the...

Do we have published research suggesting this ? If not how can we find out for certain ?

Does this proposed mechanism explain ME/CFS arising from exposure to organophosphates ?