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Thanks to AI, I found a potential association of ALDH18A1 with Hypermobile EDS. From the study text, observe they are using Network Analysis : Link : https://www.mdpi.com/1467-3045/47/2/134

Just to say regarding cases of mild ME. It took me quite some time to connect this but in retrospect I have always had issues with energy. I was 18 years old and when I was on holidays with my friends I was unable to go through a full day with them. I would need to go back at my room and rest...

Agreed, this is the wording I should have used.

I guess that "Investigation" here would include making sure as to whether a) These patients have indeed ME/CFS b) whether "remission" is indeed remission and c) whether these symptoms can be attributed to something else. From what I understand so far, there is no research group or patient...

Obviously Ron Davis believes he is doing something which is worthy. The same for Renegade Research I suppose.

I largely agree but I would like to say something about the "supplements" part of your answer @Trish Do TUDCA, Phosphatidylcholine, Mixed tocopherols and tocotrienols (=Vitamin E), Ubiquinol, LOLA (L-Aspartate, L-Ornithine) fall into the category of supplements ? -TUDCA lowers ER Stress (ER...

Dear All, I am trying to identify as to whether a mechanism / methodology exists for investigating the validity of remissions of individuals with ME/CFS, tagging @ME/CFS Science Blog , @Trish and @Andy . I now have two individuals with whom I am in contact who are in remission from ME/CFS...

Looking at the study and the comments by @ME/CFS Science Blog on FGF21, I would like to share some potentially helpful additions. @ME/CFS Science Blog mentions that FGF21 "is a metabolic stress hormone and increased levels have been found in conditions such as obesity, mitochondrial myopathies...

Speaking of depression I wonder if questionnaires used, specifically asked whether episodes of depression occurred before MECFS and not after getting it.

Yes I also agree that glutamate metabolism may be something to research further

Would glutamate dysregulation and excitotoxicity fit here ?

@forestglip A Fibromyalgia patient who also had ME symptoms has contacted me after many years. She found she has the ALDH18A1 mutation and she has issues with spastic paraplegia. From what I see this mutation leads to hyperammonemia (which she has). Taking certain aminoacids has changed her...

@Jonathan Edwards I guess we should investigate whether we have actionable results or not, whoever or whatever outputs these hypotheses is irrelevant. I hope we can agree on that. Please have a look at what Derya Unutmaz (Professor, biomedical scientist, human immunologist, aging & cancer...

LLMs now have now reasoning capabilities that we can definitely use. There are numerous cases where LLMs have found solutions to medical problems of individuals. I see no reason for LLMs not being able to put the pieces of the puzzle together for us (if this hasn't happened already that is - and...

The following hypothesis was generated using a multi-reasoning approach which uses 5 #AI reasoning engines. The latest hypothesis is as follows given the input data. Note that the model includes ways to check the validity of this hypothesis : and the proposed interventions (which have many...

GOBP_PEPTIDYL_LYSINE_ACETYLATION → Acetylation of lysine residues in proteins. GOBP_PROTEIN_ACETYLATION → More general acetylation of proteins. GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING → Binding to enzymes that attach ubiquitin or ubiquitin-like proteins to targets. GOBP_PROTEIN_ACYLATION →...

Apparently interferon signaling gets a high relevance ranking from the best performing #AI reasoning engine I have been working on and there may be more connections with CH25H. @TamaraRC please let me know if CH25H is relevant with your reverse cholesterol transport hypothesis. From a tweet ...

Good to see that we have convergence to specific research targets. First, the theory of @TamaraRC regarding Phosphatidylcholine and the importance of cell membrane integrity ...

Very happy to see that the potential importance of Phospholipids emerged via PRDX6 and AI suggests a central role in the pathology :

It is AI which has analysed the DecodeME Preprint and candidate genes. Would be great to know whether the content it produces is utter nonsense or not so I am not putting any extra effort for nothing.