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I looked at what kind of cells have the highest concentrations of phospholipids. This is what I found (using AI) : 1. Myelin-Producing Cells (Oligodendrocytes and Schwann Cells) These cells are widely considered to have the highest phospholipid content by dry weight. They produce the myelin...

Sure, the image shows how machine learning, certain causal inference methods and network analysis have found earlier (by a median of 7 years) than conventional research several research targets. Yes it shows studies that have confirmed these earlier findings. What is worrying is that there is...

This is how it is looking at the moment. As I mentioned in another thread, It is really great that all of our conversations are being recorded here for future reference. Entries in red are preprints

OK I did a second pass of the study and I believe that the PTDSS1 upregulation could be a cause of impaired efferocytosis. From the hypothesis named "A Proposed Mechanism for ME/CFS Invoking Macrophage FcγRI and Interferon Gamma" from @Jonathan Edwards , we read : "Even if generated locally...

@DMissa @MelbME Congratulations for your work ! tagging @TamaraRC Please read the following as it contains information which can be of interest related to cell membrane, cholesterol sulphate and LXR These results may also be pointing to efferocytosis apart from cell membrane remodeling...

Since this took place on Twitter , I can post here. Michal Tal (https://talresearchgroup.mit.edu/team) from MIT came across my work (dialogue at the end of this post) and wanted to connect. I was not aware of her work. Apparently she is looking at CD47 + SIRPa , Mitochondrial stress and...

I was given heparin and for 2 days I had no symptoms which then came back gradually. I am very interested to see responses with warfarin and whether these drugs brought adverse effects

Just to add a short comment, PTMs were indeed a signal in my analyses and I believe there are plausible hypotheses as to why PTMs may be disrupted. A post from @chillier ...

Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (POTS), Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways Background: Pre-COVID-19 Postural orthostatic tachycardia syndrome...

@hotblack Thanks, I do see my message correctly. Unfortunately I do not have time to do this but from my experience silhouette coefficient usually gave good results in optimising K. It would be great if multiple methods were pointing to the same K obviously but.. So I went through the results...

@hotblack @forestglip Forgive me in case this question is answered already in the thread / github. I saw you use cluster analysis. Did you use only silhouette measure for optimal K ? Did you ran others as well (e.g. NbClust?)

Regarding the paper above. From the study, we read : @Jonathan Edwards would you say that given the numerous studies pointing to protein folding issues, Endoplasmic reticulum stress appears to be a key mechanism for the symptoms of ME/CFS?

The slides of the video can be found here : https://docs.google.com/presentation/d/1Pd4pSm6PM1teiaCWXFrM8Sfn6No6spKnhWr9rWUWTuo/edit?usp=sharing

Yes I have this upon waking up. I tried to find a pattern meaning to stay in bed covered (so no difference in temperature no difference in posture ). It starts upon properly waking up and only in winter time. Really strange. Note that I have high IgE

I uploaded this video where I post a hypothesis given my 10-year research and latest studies. I will send it to researchers and patient organisations. As always your views -especially the ones that identify errors and incorrect claims- are most welcome.

Thank you Peter. Just to say that in my response I did not have the time to explain what I mean by "negative bias" and the right context. Yes I agree, every single recovery needs to be screened in order to avoid any false claims. Yes. Again, I was refraining all of these years to post details...

Thank you, I totally understand. I do not want to derail the thread so I will not comment further. Let's say I have been trying to identify the pros and cons of this methodology. I agree. If you look at a thread earlier I linked, I propose that there may be patients with key metabolic defects...

Well, in the case of Witney Dafoe and the amazing change of his symptoms we could say that we look at individual elements from patient recoveries (like myself) and then see whether we find any commonalities. I will add my two cents here. If indeed the GWAS results suggest brain and glutamatergic...

Thank you for your reply, I see one aspect of confusion on my behalf here. My mistake. When I mentioned replicated findings I meant that specific medical concepts that have been identified as being important in -say 2016- have been found later (say 2023) by published research. Thank you for...

The negative bias I was referring to was the fact that in your comment you chose to leave out "red flags" I mentioned in the thread related to BF protocol namely the fact that different versions of the protocols exist, that it makes the assumption that all patients are the same, that it has no...