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Importance Many patients with post-COVID condition (PCC) experience persistent fatigue, muscle pain, and cognitive problems that worsen after exertion (referred to as postexertional malaise). Recommendations currently advise against exercise in this population to prevent symptom worsening...

Worth noting that Nature Scientific Reports isn't a particularly prestigious journal @dave30th, it's by far the least significant publication attached to Nature. Some of the controversies on its wikipedia page include: - The face of Donald Trump was hidden in an image of baboon feces in a paper...

I think it's incredibly complex when medicine and geopolitics become intertwined - as we discovered when it came to the origins and airborne transmission of covid-19. I will say that this does seem like quite a convenient moment for the attacks to be linked to Russia given that there's waning...

This is all my greatest fear concerning Long Covid research - that any progress will be undone by a failure to define and stratify what is a highly heterogenous condition. If for an observational trial, scientists take blood from a set of patients that ranges from those with post-COVID ME/CFS...

Interesting article from Leonard Jason. Here's an excerpt: https://undark.org/2024/03/28/opinion-define-long-covid/ In 2023, the National Institutes of Health’s RECOVER consortium developed an influential long Covid case definition using a survey of nearly 10,000 participants. These...

Janna Moen, a neuroscientist who's working in Akiko Iwasaki's lab at Yale and has Long Covid/ME herself, has just written a piece on the history of ME/CFS as part of her substack "Long Covid Research Breakdown."...

They reference a study at the Royal Free from 1990, which caught my eye because a separate participant in that study told me to take sertraline two months into my illness. Not knowing any better, I listened to them. It probably helped dull my senses during an incredibly difficult time, but it...

This was a remarkably cynical move. The study was released as a pre-print a month ago, but the public health director chose today - Long Covid Awareness Day - to do a highly polemical press release about it. Australian Long Covid advocates have organised a campaign where they light up key...

I wish it wasn't the case, but none of those things constitute research misconduct. Now it may be the case that when people dig sufficiently into the data, instances of misconduct do emerge - I doubt this will prove the case, but maybe they falsified data. More likely in my view is that, from an...

It's certainly not ethical or acceptable, but it's also not research misconduct, and academics will obsess over those kinds of distinctions. There's certainly overlap between the political and scientific, but I was more trying to draw a distinction between a) the kind of advocacy that followed...

I'm afraid an academic imposing their pre-ordained conclusions on research is a pretty everyday occurrence. It of course goes profoundly contrary to the principles of academic work, but that doesn't prevent it from constantly happening. An often-quoted refrain about the study of history goes...

RECOVER is a very different equation to this study. They were essentially, due to the longstanding neglect of ME, trying to understand what they saw as a new disease entity from scratch. They spent the money poorly, but some of that was to be expected. Perhaps the most significant problem with...

I think this is the politically smart response to the paper - skate over its conclusions and serious flaws, and use it to call for proper funding from the NIH. The truth is that an $8 million study looking at 17 patients wouldn’t be expected to make serious inroads in any other field. The paper...

The only solution is sustained and large-scale funding for biomedical research. Simply refuting their arguments and pushing back against them will never lead to a lasting victory - many of the major BPS figures are still very active and vocal following the PACE trial, which was as big a public...

I largely agree about Long Covid being a medical mystery - clearly we have an incredibly incomplete understanding of what's driving the illness. It's difficult to capture all the nuance in a 1000 word op-ed - we had to cut the article down from about 1800 words. That paragraph on the biomedical...

They seem to have fixed the problems on the website, phew

So we initially wrote the article as a rebuttal to a piece in Time essentially calling for an end to biomedical research into Long Covid. We soon found out that magazines very rarely publish rebuttals, so we had to shift the emphasis a bit. We sent it to Gavi because I'd noticed that their...

Alongside a team of three fellow longhaulers, I published an article calling for scientific ambition in our efforts to understand Long Covid and ME/CFS. https://www.gavi.org/vaccineswork/long-covid-patients-need-scientific-ambition-not-defeatism We made sure to have an extended section on the...

It drives me up the wall that no Long Covid researcher has tried to replicate the nano-needle finding in a well-defined post-covid ME cohort. There are now various efforts to replicate the microclots and cortisol findings, which are clearly important. But the PNAS nanoneedle study has to be...

Ah yep, the NIH reporter website suggests the funding is just for 2024. Also saw someone say that it’s common practice for the NIH not to award the whole grant up front for a trial, they provide the money one year at a time. So we could be talking $25-30 million overall for the trial...