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It gives me diarrhea

ME caused me constipation during the chronic phase. I never had constipation my entire life. During the acute phase I had IBS and diarrhea. After going on this diet the constipation greatly improved.

Would our body and cells keep us in ketosis while it’s filling glycogen stores when our blood has plenty of glucose? From my understanding you come out of ketosis right away, but I could be wrong. I know it might be a stretch, but a theory could be that gut dysbiosis (SIBO, subacute d-lactic...

I’m still doing well on this diet, much the same as described before. As long as I stay away from carbs the symptom improvements persist. I tested going back on a regular healthy diet with carbs for two days and what I found is that it takes around two days for ME symptoms and severity to...

One interesting piece of evidence I’ve read is that d-lactate is thought to interfere with cellular respiration, namely pyruvate and l-lactate metabolism. Here’s one of a few papers which mentions it D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

@Trish and everyone - been reading a bit on gut issues since my last posts and also been on threads on PR regarding SIBO and d-lactate acidosis. Trish regarding your idea on SIBO or other gut dysbiosis being the underlying reason PWME who significantly improve on IF and keto is very...

For me like @Keela Too it’s not at all hard to get enough fat on the diet, it’s to get adequate protein. I’m supposed to eat 100g protein a day and I have to actively think about getting in protein to meet the goal. With fat it’s so easy...

I don't know how one would be able to afford a biologic without insurance, at least in the U.S. Stelara costs $10,000 1st 0.45mg starter injection + $10,000 2nd 0.45mg starter injection 4weeks later + $21,000 each 0.90mg maintenance injection every 12 weeks after. :wtf: Stelara (ustekinumab)...

Update: It's been just over two weeks now since I recovered from the crash I had after starting the ketogenic diet (see earlier in this thread). I had transitioned and was on the ketogenic diet for two full weeks before that crash. These two weeks I had more activity than the two weeks before...

I used Elidel to treat my psoriasis for years before I got on an anti IL-23 biologic this year. It worked well though not for itching so I had to combine it with a topical steroid sometimes. It significantly improved my patches and made a couple go away but they would always come back within a...

@Sid the thing is that ME researchers are, I believe, finding more and more evidence that comes to the conclusion that this is a heterogeneous disorder. That the causes, triggers, and possibly even drivers of the disease are different between patients and though we all end up in pretty much the...

I totally agree. But this post gives a more fair and balanced assessment of the situation, some women will do better with ketogenic and IF intervention, some won't. We can't say that all woman will do badly because honestly we don't know.

Sorry @Sid I accidentally hit post before I was done. Please re-read my post as it changed.

Probably no. I would say a possible theory is that due to the fact that we keep eating carbohydrates like normal and we have a healthy supply of glucose in the blood our bodies do not utilize ketosis in any significant way. If this theory is true, it seems that our cells do not get any signal...

I wouldn't make such a blanket statement. Naviaux doesn't know for sure. His paper studied 45 subjects (n = 22 men and 23 women), that's a very, very small study. I know that Fluge/Mella also found some evidence in a much larger cohort but I think we are mixing up the scientific findings and...

PWME do not have genetic mitochondrial diseases. No researcher, no doctor, no patient, no one knows exactly the cellular energy impairments we actually have, and how different or not they are to congenital disorders. I wouldn't go so far to make that extrapolation. We have no idea. Most PWME...

What you wrote in the first paragraph is basically my own experience and that of others. @Trish's theory that it could be SIBO is a valid one, but you cannot prove that it isn't cellular metabolic impairments that are suggested by a number of high quality ME research studies. There are no high...

Sorry I'm very busy today... just keep searching it's there. It isn't required but it is used to jump start and help you get into ketosis. Otherwise it can take much longer...

Here's a long-term study on the ketogenic diet in (mostly) adults with epilepsy. Mean diet time was 9 months, with five patients continuing for >= 23 months. "The diet was generally well-tolerated, but undesired weight loss and constipation were the most frequent adverse effects." Ketogenic...

@Sid I apologize but ketogenic != Atkins. With Atkins you replace carbs with as much protein as you want (and the fats that come with it). Ketogenic you only eat the amount of protein your body needs and no more and you replace carbs with healthy fats.