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  1. leokitten

    Aripiprazole - Abilify

    At least in my case whether it’s “masking” or doing more taking LDA in cycles like this doesn’t have any permanent baseline worsening effect I know it’s hard to convey clearly but the way it truly feels for me is that it’s not masking but that dopamine dysfunction is in my case a downstream...
  2. leokitten

    Aripiprazole - Abilify

    It doesn’t totally dissipate it just gets to the point where it’s decreased enough that I know it’s best to stop and take a break. But if I keep taking it it continues to have some effect that improves my baseline a bit.
  3. leokitten

    Mast Cell Activation Syndrome (MCAS) - discussion thread

    Doesn’t GWAS have some pretty big limitations? Particularly only picking up a small subset of traits and therefore link to illness
  4. leokitten

    Aripiprazole - Abilify

    Don’t know why I didn’t post this sooner, to show the LDA sceptics that for us temp responders the effects are real. From my phone health app My housebound baseline is in the few hundreds and you can see for months that’s how I am between LDA cycles. During LDA it shoots up to 7-8k and more...
  5. leokitten

    Systemic increase of AMPA receptors associated with cognitive impairment of long COVID, 2025, Fujimoto et al.

    What’s so incredible about this potential dx biomarker is they got 100% sensitivity and 91% selectivity, I don’t think I’ve seen any ME/LC research biomarker do so well
  6. leokitten

    Is ME/CFS a form of Host versus Host disease?

    Would this theory fit with the possibility that such peripheral immune dysfunction or activation could negatively affect the CNS through various pathways giving rise to some ME symptoms?
  7. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I just miswrote that sorry was reading something on plasma cells and plasmablasts and mixed it up
  8. leokitten

    Orexin effect on physiological pulsations of the human brain, 2025, Jarvela et al

    https://medicalxpress.com/news/2025-09-brain-pulsations-people-narcolepsy-resemble.html
  9. leokitten

    Orexin effect on physiological pulsations of the human brain, 2025, Jarvela et al

    Significance This study establishes how narcolepsy type 1 (NT1) affects brain fluid dynamics through lack of orexins by comparing NT1 patients to healthy wake and sleeping controls. Using fast functional MRI, we revealed that even during wakefulness, NT1 leads to high vasomotor and low brain...
  10. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    If anyone has the energy right now to query MacroMap and to see if anything from DecodeME comes up
  11. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    https://www.sanger.ac.uk/news_item/activated-immune-cells-reveal-hidden-drivers-of-autoimmune-diseases/
  12. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    Merged thread due to being very related ---------------------- Splicing QTL mapping in stimulated macrophages associates low-usage splice junctions with immune-mediated disease risk The majority of immune-mediated disease (IMD) risk loci are located in non-coding regions of the genome, making...
  13. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    https://medicalxpress.com/news/2025-08-immune-cells-reveal-hidden-drivers.html
  14. leokitten

    Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases, Panousis et al 2025

    Many disease-associated variants are thought to be regulatory but are not present in existing catalogues of expression quantitative trait loci (eQTL). We hypothesise that these variants may regulate expression in specific biological contexts, such as stimulated immune cells. Here, we used human...
  15. leokitten

    The symptom signaling theory of ME/CFS involving neurons and their synapses

    Yep if it turns out to be a neurological CNS illness that is frankly indistinguishable from being neuropsychiatric we are all well and truly fucked, period. This would be devastating
  16. leokitten

    The symptom signaling theory of ME/CFS involving neurons and their synapses

    Many of us would disagree somewhat with this belief, because for us the first couple years or so of ME it felt very, very strongly immune system driven, like our immune system was stuck in some strange chronic activation. Many of my lymph nodes were constantly swollen and hard as a rock and I...
  17. leokitten

    Can Large Language Models (LLMs) like ChatGPT be used to produce useful information?

    They are all full of shit and mostly just grifters. LLMs do not scale that much is known. So they are a dead end really the way they are currently designed. They will need another huge discovery like transformers were for LLMs before another major advance can be made, and guess what no such...
  18. leokitten

    Can Large Language Models (LLMs) like ChatGPT be used to produce useful information?

    Given the latest news about GPT-5 I would say LLMs have hit a wall and are way more hype than substance. https://www.latimes.com/business/story/2025-08-20/say-farewell-to-the-ai-bubble-and-get-ready-for-the-crash
  19. leokitten

    The symptom signaling theory of ME/CFS involving neurons and their synapses

    It would be very disheartening, and in my opinion difficult for scientists, if ME turns out to be a purely neurological disorder like described in this theory. Neurological and neuropsychiatric disorders where the source of the disorder is seated more or less completely in the CNS are some of...
  20. leokitten

    The symptom signaling theory of ME/CFS involving neurons and their synapses

    Can this theory also explain how so many of us have peripheral immune symptoms and comorbidites after getting ME? MCAS, worsening of preexisting autoimmune or autoinflammatory disorders, sudden new autoimmunity. Could central signaling issues directly trigger these?
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