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https://www.pnas.org/content/117/11/6170.long The Guardian: Low-carb diet may reverse age-related brain deterioration, study finds

Full title: Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial. Athinarayanan et al. Front Endocrinol (2019)

The Guardian: Gary Taubes: 'Obesity isn’t a calorie problem, it’s a hormone problem'

They want segregation and this is what is disgusting to me. History has shown where that ends up. Some kind of “separate but equal” research and understanding between what is looking like one illness with two names for a significant subset of people. When you look right now at all the evidence...

I’m confused by what you wrote, the list of approved and currently in use drugs I provided before the NYT link include both novel drugs developed for COVID (remdesivir, monoclonal antibodies) and repurposed drugs (baricitinib, dexamethasone) that each have been shown in trials to significantly...

Love the analogy :woot:

Well put, thought the same thing after reading about all these theories over the years.

Huh?? Remdesivir, bamlanivimab, casirivimab + imdevimab, baricitinib, dexamethasone, etc, and more coming https://www.nytimes.com/interactive/2020/science/coronavirus-drugs-treatments.html Almost as many as the number of vaccines under research and just as many approved if not more already in use.

Scientists May Have Finally Found a Key Mechanism Behind Irritable Bowel Syndrome

Yes totally, as a researcher you want to do those “low hanging fruit” experiments that could disprove your hypothesis as quickly as you can. Then if it turns out badly you quickly move on and refocus resources to other hypotheses. I feel the same with the IDO metabolic trap hypothesis, there’s...

My onset wasn’t like that. Right from the triggering viral infection my immune system went into maximum overdrive. I had very swollen hard lymph nodes all over my neck and groin. Heart arrhythmia, random nausea and vomiting, fever and night sweats, and many more symptoms of immune system...

Very interesting didn’t know this

@Jonathan Edwards regarding psoriasis and whether defined as autoimmune or not, the last few years there’s been developing research on the presence of autoantigens and autoantibodies in psoriasis and psoriatic arthritis. Of course will take more research and time to determine if this is indeed...

Multiple Sclerosis News Today: BioNTech Vaccine Treats MS in Mice Without Dampening Immune System

Interesting blog article on this paper and other uses of this technology, variations of which are potentially relevant in future if research discovers ME is due to chronic immune activation and what are some of the targetable pathways to bring back tolerance without suppressing the immune...

The authors of this paper are the same BioNTech scientists who created their COVID vaccine.

Here’s the paper

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. Li et al. J Neuroinflammation 2019

I’ve just thought why aren’t Prusty, Davis, others testing mdivi-1, a small molecule inhibitor of mitochondrial fission (Drp-1 dependent) that also crosses the BBB, with ME/CFS cells to further understand if mitochondrial fission/fragmentation are indeed playing a significant metabolic role? And...

Ok, though hope I’ve been coming across that I wasn’t referring to the daily low-dose steroid regimen as this you are right doesn’t help for many. But this is different than periodically taking a single immunosuppressive (so much higher) dose of stronger steroids before significant exertion...