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Relevant to ME too and how we can perceive ourselves after loss due to this illness and how we can be negatively perceived by others.

Because research is very incremental, single papers aren’t meant to be the end all be all. It was an initial step. Most single research papers don’t tell us much. Look for example at the recent Hanson proteomics paper, I would say the exact same thing it doesn’t tell us much at all. Doesn’t...

I believe the paper didn’t suggest this, and yes you are right a retro study like this has major flaws/limitations. But it’s a start and I believe the last two sentences of the paper are to me the gist of the intent of the paper:

True they should’ve mentioned something, but no there are reports of the drug continuing to work without tolerance in a minority of patients.

This has already been litigated ad nauseum in other threads, the list of side effects and negative information people always cite is for much higher antipsychotic dosages, not 2 mg/day or less. As @Jaybee00 stated, in a subset of patients the drug seems to lose efficacy after ~4 months of use...

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01395-9

I understand that and indeed it could be true, but the two studies you referenced didn’t account for disease severity as a confounding factor or otherwise. We just don’t know and more comprehensive studies accounting for important clinical and demographic data should be done. As a person who’s...

Both of these small studies were referred to in the hypothesis paper. There were some important flaws in these studies, like not looking at disease severity or length of illness. Remember pathophysiology isn’t only what disordered processes are occurring in all or most cases of ME/CFS. Some...

I encourage people to read the entire paper. Endocrine dysfunction hasn’t been studied to death in ME. Nothing has been studied to death in ME there’s never been any money to study anything to death we don’t know anything about this disease. Even the studies that have been done all have serious...

I would encourage people to read up on the functions of the hypothalamus and pituitary gland. This system is central to maintaining homeostasis and directly performs or regulates so many vital bodily functions. To me it’s no surprise that any dysfunction arising from this system would have...

Both Fluge & Mella and Ron Davis do not know if it’s a single factor that’s in the blood causing metabolic dysfunction. I’ve always wondered why they think it’s one thing when they have no evidence yet to show that. This hypothesis says that multiple aberrant levels of hormones, cytokines, and...

I know this is total speculation, but maybe the people with CCI/AAI and ME had pressure on their hypothalamus or pituitary gland due this condition and surgery possibly relieved this pressure causing ME remission or improvement?

I read in the chronic critical illness literature that taking exogenous hormones are not the way to go and can actually make things worse. For example they trialed HGH in critical illness and discovered it did the opposite of what they expected, it significantly increased illness severity and...

The authors already referred to the type of initial study to disprove the hypothesis. It doesn’t require any complex experimental methods or technology. It looks at a key part of the hypothesis by taking direct hormone measurements from blood, unlike for example cytokine, metabolic, and...

I generally don’t write comments but had to reply to a comment on the article calling it “sensationalist” and citing a single medRxiv preprint study from earlier last year suggesting 2.5% of symptomatic COVID cases result in LC. My reply under “Leo” https://nyti.ms/3c2HW4V#permid=111219638

What kind of psychological mumbo jumbo is “building your own healing capacity”?!? Would you say that to cancer patients, heart disease patients, MS patients, lupus patients? Please go away and build your own critical thinking capacity.

Exercise “targets”?

Another feature article from the same issue: NYT Magazine: My ‘Long Covid’ Nightmare: Still Sick After 6 Months

Long read because it’s NYT Magazine so not as newsy, traditionally comes with the Sunday NYT newspaper. Also it’s a “feature” article format, which I believe is their longest format reserved for leading articles in that issue.