Search results

Just because something isn’t a scientific paper doesn’t necessarily mean it’s an advertisement. Papers are referenced in the YouTube video and OP article. Whether you think the way they try to tie the referenced papers to the theory is poor is another matter and that’s totally valid.

I would agree and say there’s only one problem with the analogy, we do not generally know what treatments would’ve worked for many ME patients very early on in the illness, whereas LC patients are trialing things quite early on. Not saying this would work, but it’s a big unknown as most pwME...

YouTube series on the biology of NAD+ deficiency and Long COVID and interview with Dr. Ade Wentzel

I’m just putting out info for members to discuss and judge, not necessarily a believer or proponent of this theory.

Maybe I missed something in the paper, but I don’t think it was cherry picking but that they were missing data for some cases. I would agree with you here IF it could be said that the retrospective analysis endpoints were robust. They weren’t in my mind which really makes it hard to judge the...

I agree wholeheartedly with this, the BPS folks give the rest of psychiatry a bad name, because at least here in the US psychiatry believes and there’s an ever increasing mountain of evidence to show that psychiatric disorders have a neurobiological basis. There is also a very fuzzy line between...

The Team of Doctors and Biohackers Who Seem to Be Successfully Treating “Long Covid” There’s actually quite a number of research papers on this.

As long as they design the damn RCT properly! Not like the OSU6162 RCT where they gave the drug for only 2 weeks! Let’s get the trial dosages right, the treatment time course right, and physical and cognitive endpoints right! I think we pwME collectively sigh and shake our heads as much or more...

Ok, just wondering in relation to the recent Younger DXM trial not showing significant efficacy and whether the FM evidence base on microglial activation was stronger than in ME. They chose DXM because it inhibits microglia so wondered if it was a surprise that it didn’t work. I personally have...

May I ask those who’ve been following FM research, is the evidence base for neuroinflammation in FM and stronger than in ME?

I’m currently going through the process starting a few months ago. I keep vacillating in my head it’s really hard. It’s like society brainwashed us into only being able to think of yourself in one way and everything else is a failure.

Going back to Abilify and this paper, have we ever seen any other treatments have such a positive effect on so many very severe and severe pwME? I know that very severe or severe pwME are not totally immune to placebo effect, just wondering when you are so very sick every second of the day if...

This paper is definitely better than the Abilify retrospective paper, even though it too has limitations being single-arm open label. OSU6162 and Abilify are quite similar drugs and are dopamine and serotonin system stabilizers. What do people think about the various endpoints? I don’t feel I...

Am I completely misreading the study design? To me the major design flaw in this study and possibly a huge reason why they had a null result is because they only gave the drug for 2 weeks. They did a follow-up 6 weeks after starting the trial but patients did not take the drug or placebo for 6...

https://www.thecut.com/2021/02/who-are-we-without-our-jobs.html

Trazodone - StatPearls - NCBI Bookshelf

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial. Lopes et al. RMD Open (2021) The Guardian: Gout drug could reduce Covid hospital stays, new research finds

Really so taking an antidepressant would jeopardize your ME disability claim too? Or taking LDN would jeopardize it because it’s a drug used to treat alcohol abuse in higher doses? Remember the most widely used indication for Abilify (5–10mg per day) is as an add-on med to antidepressants...

Not an agonist but a functionally selective dopamine stabilizer, like Abilify (in addition to the serotinergic mechanisms Abilify has) Dopamine agonists (like pramipexole, rohpinirole) anecdotally haven’t shown any benefit in ME except for a handful of cases.

I think most everyone is adult and able to inform themselves enough to evaluate the pros/cons with their ME doctor and then weigh the personal decision on whether trial Abilify or not. Given that it is a generic, cheap, easily accessible drug with a low risk of adverse effects at the dosage...