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I totally agree. Given though what I and many others are (or have) experienced with low-dose Abilify really says to me that likely there are different ME pathophysiological subsets and/or people misdiagnosed with ME, since there were those in the Stanford retrospective study that had minimal or...

I’m taking moclobemide (RIMA MAOI) at the lowest therapeutic dose of 300 mg/day. I’d been taking moclobemide for over 2 months by itself before and had no significant improvement other than some very minor improvement in mental energy only when lying in bed. If I started getting up and exerting...

You could’ve written this about me too. I had same the experience as you @benji. I’m also trialing Abilify 0.5 mg and have had a really significant improvement on it. I’ve been bedridden 22-23 hours a day for 5 months and was housebound before that all of 2020 only able to go outside once every...

I totally agree. But this is another problematic dimension regarding ME RCTs. Though even if you have well-crafted, physical quantitative endpoints etc, if there are subsets of people with different pathologies or misdiagnosed ME all mixed in the same trial nothing will save it.

Spot on

It’s just he stated, and I’m paraphrasing, that LC and CFS are distinct because LC has what can be described as a old/broken battery. That why I didn’t understand how that answer could be a misunderstand of any question. So god knows how many BBC viewers saw that and they believe that now. But...

I know this has been discussed before, but maybe worth bringing up again. Regarding ME treatment RCTs, I generally worry about the chances of success without at least some knowledge of pathophysiology. There is some likelihood that there are significantly different ME pathophysiological subsets...

Has it been shown that steroids are ineffective in ME/CFS in very short-term usage? I understand they aren’t a usable long-term treatment, but I didn’t know they were proven ineffective for very short-term use, at least for an ME subset.

I think Syk elevated CRP assumes the inflammation is systemic or at least outside CNS? I believe that Syk and Src are part of a microglial activation pathway. So maybe the “inflammation” (I know, you don’t like this word in relation to microglial activation) is in CNS and you wouldn’t see...

The pharma company that discovered aripiprazole already has a new FDA approved drug for the same indications, brexipiprazole (Rexulti). So I have my doubts that the authors of the paper, if related to the company at all, have this as a principal intent.

To me the paper is interesting not in relation to COVID-19, but to possible (hypothetical) mechanism of action in ME/CFS.

Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic. Yoo et al. Biochem Pharmacol (2018)

Abilify’s potential anti-inflammatory and immunomodulating characteristics... Aripiprazole as a candidate treatment of COVID-19 identified through genomic analysis. Crespo-Facorro et al. medRxiv (2020)

It makes me sick to my stomach (figuratively). Seeing for example that Strain BBC interview where he’s saying the LC to ME distinction can be described by old battery analogy in LC and his blatant ignorance and arrogance (for not bothering to spend the effort to read up on ME/CFS or talk to ME...

I agree, I think it’s only some possible clues and for me it didn’t work nearly as well months later, but it was really interesting to experience what happened. We also still don’t know if all of us diagnosed with ME have the same underlying pathophysiology.

This paper adds to the evidence base that is in line with those of us who had a rapid and significant improvement on a ketogenic diet, albeit temporary in my case for a few months. While I agree it’s likely not a long-term treatment, patient treatment testimonials can give us some clues to...

Given that initial LC studies show a pretty even prevalence between men and women, I’m wondering if this is initially true of most other PVFSs and that more men recover over time revealing the 75% women 25% men ME prevalence of those who don’t recover.

Look up AMPK function

Because peripheral blood is very easy to sample and in blood you basically only have white blood cells, red blood cells, and platelets. The latter two aren’t useful to study in this context, so lymphocytes are selected from WBC. They could’ve selected other WBC types though not sure if there’s...

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