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We need sufficient levels of magnesium for converting vit D into its active form. I had very low vit D levels over 25 years ago but taking supplements didn't help much until I took magnesium shots and my D levels went up by taking 1000iu to 2000iu/daily.

Authors from the Department of Occupational Therapy, Prosthetics and Orthotics, Oslo, Norway and one from the Center Biostatistics and Epidemiology that came up with a conception or mental image of something to be done. Do they think we need to learn how to walk again?

The D-lay MS trial had their participants take 100,000ius every 2 weeks for 24 months. Conclusions and Relevance Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitting MS. These results warrant further investigation, including...

Abstract We tested the hypothesis that high oestrogen [E2] and progesterone [P] increase minute ventilation (V̇E) and work of breathing (WB) during hypoxic exercise in the midluteal (ML) compared to the early follicular (EF) phase of the menstrual cycle, and in post-menopausal females using or...

Dr. Hyde referred to ME as a vascular disturbance of the brain, or cerebrovascular disease. Wouldn't that fit more with what we are experiencing concerning blood flow and cognitive issues?

Fast forward 2 1/2 years later . . . we had a wolf (woof) problem. Our coop was pretty secure so this wolf couldn't figure out how to get in, but he tried and continues to come around after dark (about 7pm), and instead of going out and socializing, he continues to annoy pwME and LC...

New vulnerability discovered in the bacteria that causes the disease The study was published Nov. 13 in the journal mBio. “Our work shows that manganese is a double-edged sword in Lyme disease,” said Northwestern’s Brian Hoffman, who co-led the study with USU’s Michael Daly. “It’s both...

Zero 'likes' on this one for PG suggests a profound lack of success, even below the baseline expectation of zero.

Did we miss PG reply to Rob Wust re Questionnaire regarding PEM? "Post exertional malaise is a symptom generated in the brain. Graded exposure therapy accompanied by a brain-body explanation helps recovery. Belief it is a solely biomedical phenomenon influences unconscious beliefs, increases...

Researchers in South Korea have presented a new technology for restoring dental tissue using biodegradable patches or gel that stimulate the natural regeneration of dentin — the hard tissue located beneath the enamel. This new approach has the potential to revolutionize traditional dental...

The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex Imagine what repurposed drug they'll discover for delayed PEM? We might not like it but what if it works?

Thanks for this. I've unignored this thread and put it back on "watch". I'm in it just for the entertainment now!

Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results. NEWS Nature: November 26, 2026 Engineered immune cells are being used to successfully treat people with a range of debilitating autoimmune conditions, such as ulcerative...

I use the term cognitive deficiencies which is closely linked to disruption in brain energy metabolism. That's the the term I used to describe my cognitive issues to my GP. I also included "lack of blood flow to the brain feeling" to describe orthostatic impairment because I wasn't sure if...

1/n. I want to clarify my earlier comment. I was annoyed that the patient statement about the questionnaire was not accurate and I was not involved in this patient participation step, which contributed to confusion. I’m sorry for the distress this caused... 2/n Some information shared publicly...

It's not from a study, it's based on a close friends experience. He had hypoperfusion on his first SPECT and PET scan which got him disability benefits, after retesting years later it came back normal, but his brain felt more toxic/poisoned. He had ME/CFS for 18yrs.

Hypoperfusion can resolve in pwME but their condition continues to worsen.

Abstract Background The AMPK/SIRT1/PGC-1α pathway serves as a central regulator of cellular energy homeostasis, coordinating metabolic stress responses, epigenetic modifications, and transcriptional programs. Its dysfunction is implicated in the pathogenesis of a wide spectrum of complex modern...

Abstract Background Cardiovascular autonomic disorders (CAD) were described following COVID-19 infection and vaccination, but previous reports were limited in size and follow-up. Here, we aimed to investigate the type and frequency of newly diagnosed and exacerbated CAD following COVID-19...

Abstract Altered thyroid function (TF), especially non-thyroidal illness syndrome (NTIS), is common in hospitalised COVID-19 patients, but adaptive responses to disease as captured by blood biomarkers in the context of thyroid signal integration require further elucidation. This retrospective...