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Abstract In the resting, non-stimulated brain, metabolic demands are met exclusively by the delivery and extraction of glucose and oxygen at an ~6:1 ratio. Amongst healthy people at rest, there is marked variability in resting global cerebral blood flow (CBF) yet remarkably stable concentrations...

The 'cog-brain' in MS certainly describes my cognitive difficulties, but it doesn't necessarily involve exertion so I wouldn't describe it as PEM related. That being said, I experience the same 'cog-brain' during delayed PEM ¯\_(ツ)_/¯

"Cog-Fog" in MS Memory People with brain fog may struggle with forgetfulness. They may have trouble remembering people’s names, recent events, or preplanned tasks. If brain fog affects your memory, you may lose objects or miss appointments. Concentration Brain fog can make it hard to...

@PageofME you might be interested in reading this story This is where I live and became ill from sudden viral ME onset in 1991. It's very interesting with the recent studies that show EBV could have a strong link to MS. "Dutrisac wants to know why 14 former neighbours — all about the...

Several contributions focus on advanced MRI applications and related quantitative imaging modalities. Gkotsoulias et al. demonstrated that deep learning-assisted reconstruction substantially improves QSM image quality in multiple sclerosis (MS), enabling clearer visualization of MS-related...

Did the study factor in or include the length of time pwME were ill?

Abstract Background Influenza viruses with pandemic potential and possible burden of post-viral sequelae are a global concern. To prepare for future pandemics and the development of improved vaccines, it is vital to identify the immunological changes underlying influenza disease severity...

"We are still looking for #MECFS patients for the validation of a new PEM questionnaire, in collaboration with the University of Vienna. Please see the post below for more information!" "We have developed a new questionnaire for PEM and are currently conducting further validation.After...

In conclusion, both maximal and submaximal exercise resulted in significantly elevated mV̇o2 15 min postexercise, with maximal exercise having a greater impact despite being matched for caloric work. NIRS appears capable of detecting a wide range of mV̇o2, making it an attractive tool to assess...

NEW & NOTEWORHTY We found that the muscle oxygen consumption rate 15 min after cycling exercise remained three- to fourfold higher than at rest. Higher-intensity exercise resulted in higher postexercise muscle oxygen consumption despite having the same total work during exercise. The...

Mito-Q supplementation did not alter redox responses to acute exercise in skeletal muscle of older adults. Antioxidant hype doesn’t always match reality.

Mito-Q supplementation does not impact redox responses to acute exercise in skeletal muscle of older individuals

You asked me this question over 5 years ago and I wrote that I didn't know, but I put my glasses on this time and here is the result: Coenzyme Q-10 2.9(reference range-0.5-5.0) µmol/L

The PG effect.

Our work points to numerous future directions that will deepen our understanding of the neuroimmune interactions that underlie sickness behavior. Our molecular atlas of immune signals in POA- and PVN-treated mice highlights dozens of candidate immune mediators that may affect the function of...

Abstract In nature, animals encounter diverse pathogens that trigger specific peripheral defense programs and elicit sickness behavior, a set of stereotyped physiological and behavioral changes thought to promote host fitness. Most studies to date have relied on one or a few mouse models of...

I don't compare delayed PEM to fatigue in my experiences. It feels like a different illness. More like weakness than fatigue.

Abstract The COVID-19 infection can cause changes on many organs, but changes in post infection period are not uncommon. The aim of this study is to detect changes in esophageal manometry parameters in post COVID-19 infection period. We reevaluated 84 patients after clinical recovery from...

That is pretty much how I feel when I'm feeling very 'fatigued'. I don't experience pain, but I get achy/sore/stiffness and not up to standing or walk for too long. It passes after a few days. When I actually have a reactivated virus, I feel out of breath easily with other symptoms...

What 'tailored treatment' are they referring to I wonder. I had mine tested 8 years after post-infectious onset M.E (all way below ref range except NK cells which were normal range) and the virologist rx'd me an immune modulator that caused a relapse and lowered my baseline.