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Vibrant Study Encouraged by these discoveries and preclinical data, Suh launched a first-in-human clinical trial. In this pilot study called VIBRANT—Validating Benefits of Rapamycin for Reproductive Aging Treatment—50 healthy reproductive-age women were enrolled. Half received rapamycin weekly...

I think Ontario is the only province in Canada that has a billing code for ME/CFS. The code allows the physician to book more time for the patient.

https://www.trentu.ca/biology/faculty-research/faculty/sarah-l-west Research Exercise physiology Exercise and bone health Exercise in chronic disease Bone physiology My primary research interest is examining exercise and bone health in various populations, including in those with chronic...

Looking forward, the development of site-selective itaconate analogs, targeted delivery systems, and activity-based sensors will accelerate the translation of these findings into clinical applications. Moreover, integrating itaconate biology with emerging fields such as epitranscriptomics...

Abstract Itaconate is a mitochondrial metabolite generated from the tricarboxylic acid cycle intermediate cis-aconitate by the enzyme aconitate decarboxylase 1 (ACOD1). Beyond its metabolic role, itaconate has emerged as a critical regulator of immune and inflammatory signaling. Together with...

The step by step advice to slow recovery isn't going to work long term and should be tossed into the bin.

Thread here

"Good to see that our results are replicated in different cohorts using different methods. Scientific research is brutal where popularism is favored over out of the box ideas. But it is also exciting to see that we are much closer to understanding this disease than before".

Abstract Epstein–Barr virus (EBV) is strongly implicated as an essential environmental trigger of multiple sclerosis (MS), yet the host genetic mechanisms governing EBV activity and how infection triggers the disease are not known. We developed a pipeline to quantify EBV DNA from whole-genome...

Years ago I took the first dose listed - 1.5mg It was unpleasant and gave me terrible insomnia.

Jarred Younger’s low-dose naltrexone clinical trial for ME/CFS has been registered. https://clinicaltrials.gov/study/NCT07285473?cond=ME%2FCFS&distance=50.0

Moved post Thread by Jeff_says_that "Over the years, it has been refined and expanded..." "Most notably by my awesome coauthors. The first peer-reviewed publication of the Mechanical Basis Model has been published" "Brainstem dysfunction as a potential etiology of ME/CFS and long COVID: A...

Reposted by Jeffrey Lubell This refers to the recently published hypothesis paper by Jeff Wood et al. Hypothesis: A Mechanical Basis: Brainstem Dysfunction as a Potential Etiology of ME/CFS and Long COVID, 2025, Jeff Wood, Kaufman et al. A post with a tweet by Wood about his hypothesis has...

I didn't even have delayed PEM or PEM like symptoms 30+ years ago during PVFS/CFS onset until years later. It was a completely different experience from my Covid infection recovery. My infectious ME onset was sudden, but the symptoms developed gradually over the years until I returned to...

When I got Covid a few years ago I would have said I had delayed PEM too if I didn't know what ME/CFS delayed PEM was. I thought I was over the Covid infection after 3.5 weeks, but after I went for my usual power walk I got up the next morning and couldn't stand on my legs for another 3 1/2...

I wasn't taken more seriously when the gynae asked me if I had any medical conditions. I said I had myalgic encephalomyelitis and she threw her arms in the air and asked 'what is the shorter version?"- I said CFS. She scribbled something down. I'd love to know what she wrote b/c I don't...

The flu strain is hitting 65+ and very young children.

My new GP was a little confused as to why it had 2 names just recently. Using ME/CFS is the best acronym as a medical term for now, even though neither describe what I actually have.

Delayed PEM lasting longer than a day has always been my experience. It has lasted longer than the 3-4 day 'normal' for me years ago when I went waaay beyond my typical energy expenditure. I'm pretty aware now about my energy limit boundaries after years of experimenting.