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Editor’s summary The mitochondrial respiratory chain consists of membrane-integral complexes that build up the proton gradient across the membranes of the cristae, thereby powering ATP synthase. Waltz et al. used cryo–electron tomography to resolve native structures of these complexes directly...

That combo would have my legs shaking too. I had a stationary bike in the earlier years and my heart rate was up within a few minutes with very little tension, my legs were shaking when I got off, but I can power walk for up to 50 minutes and climb a few flights of stairs on 'good' days...

I had no idea it was only an 8 minute cycle at an easy pace. Is this across the board for a CPET?

Ontario Premier Doug Ford when asked about ODSP(Ontario Disability Support Plan) provincial supports in Canada, “Healthy young people that are sitting on the couch watching Flintstones, they should be out there, they should be working” Totally out of touch.

I'm sorry but I was the one that confused you and should have posted it in sequence.

I link I posted before that mentions that it was an ME/CFS patient. FWIW

So basically get back to work.

Dr Gilbert has since been diagnosed with illnesses including long Covid and ME, which is also known as chronic fatigue syndrome. He is now seeking medical retirement from his job and struggles to see his children. "Being a dad was always the most important part of my life and I feel like I've...

'My close physician friend just messaged me-this is amazing: He had been following a patient with a chronic disease for many years, trying various treatments to no avail. He recently uploaded all the data to Grok, which suggested a specific treatment. Now, the patient seems cured!'

The chronic disease I mentioned below was chronic fatigue syndrome, or ME/CFS, a highly debilitating and heterogeneous disorder somewhat similar to Long Covid; thus, every patient presents slightly differently. My friend performed mass-spec analysis of proteomic expression in this patient...

Please feel free to move this. I'm having a Grok day. Grok, what are some of the worst mistakes made in clinical trials that reduce the reliability and rigor of results? [Not in any order.] "The list is on point, but daunting all together. Experienced academics keep these in mind when...

Clinical Implications: VT1 (first ventilatory threshold) may serve as a practical PEM threshold - this requires confirmation HRV tracking can help tailor personalized recovery strategies More research is needed, but wearables show promise for daily symptom management

Why it matters: HRV monitoring via wearables could help patients identify overexertion and individual PEM thresholds, allowing for better pacing and symptom management in Long COVID.

COVID patients had lower HRV during daily activities & sleep HRV remained lower for 24 hours post-exercise, indicating delayed recovery intense or prolonged exercise worsened subsequent nighttime HRV, a possible PEM-related symptom

MSc student Twan Ruijgt, together with @KasperJanssentracked 127 Long COVID patients and 21 healthy controls using continuous HRV monitoring over multiple days. Participants also underwent submaximal (!) exercise testing to determine individual ventilatory thresholds

New preprint with alert! 1/ Patients with Long COVID often struggle with fatigue, autonomic dysfunction, and post-exertional malaise (PEM). Can wearable heart rate variability (HRV) monitoring help? Our latest study suggests YES

I had this test done 2 years after ME onset but it was not an issue for me.

Abstract The Post-acute Sequela of SARS-CoV-2 (PASC) syndrome, also known as Long-COVID, often presents with subjective symptoms such as brain fog and cognitive fatigue. Increased tinnitus, and decreased hearing in noise ability also occur with PASC, yet whether auditory manifestations of PASC...

My heart rates goes up and I start to shake when my brain energy starts to 'shutdown'. I need to full stop and lie down.

I don't know if this is related here but I found it interesting. The Neurological Basis of Shutdowns in ADHD Shutdowns in ADHD are linked to the brain’s handling of neurotransmitters like dopamine and norepinephrine, which are crucial in managing attention and emotional responses. When...