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It's full stop when I start slurring my word.

Just did a quick google for cooling vests in Australia and a window popped up on the Aussie website asking, "are you sure you are in the right place?". I live in frigid Canada. @Holinger that is awfully hot where you are but no humidity, right?

I've not had issues with sleep or unrefreshed sleep unless I really over done it the day before. My sleep issues now are all related to menopause, fragmented sleep and waking up feeling unrefreshed, but as the day goes on I start to improve. I've lost the ability to have a short nap in...

Abstract Human muscle biopsies are often required to study or diagnose diseases. However, traditional approaches are challenging due to limited sample size, quality, or patient discomfort. Fine-gauge needle biopsies (≥14-gauge), present an alternative but yield insufficient sample sizes for...

Abstract A 3-hit metabolic signaling model of the causes of autism spectrum disorder (ASD) is described. The 3-hits required for ASD are: 1) inheritance of a genotype that sensitizes mitochondria and/or eATP-stimulated, intracellular calcium signaling to environmental change, 2) early exposure...

Significance This study examines systemic metabolite changes occurring throughout acute and chronic viral infections. We identified an early, transient nutrient shift in chronic infection, characterized by an increase in medium- and long-chain fatty acids. Concomitantly, a stem-like CD8 T cell...

:rolleyes:

The science of predictive processing sheds a new light on persistent fatigue Key Points The new science of predictive processing is prompting researchers to understand fatigue in a new way. Persistent fatigue may be the result of the brain's hyper-vigilance following multiple stressors...

We have a thread on Jack Amatica Patient-centred chronic disease The author of the original tweet has severe ME/CFS on his Bio. He has also tagged Whitney and another research member on S4ME.

Revolutionary Compression Binder for Orthostatic Intolerance Tested The results of the study have generated significant interest within the medical community. Leading experts in cardiovascular health and biomedical engineering are anticipating more comprehensive clinical trials to assess...

Abstract Purpose Orthostatic intolerance is a category of disorders characterized by inadequate hemodynamic compensation upon standing. In this study, we developed a portable, active abdominal compression binder intended for individuals with orthostatic intolerance. We present proof-of-concept...

I've experienced this too for many years. I refer to it as 'vestibular gait' and not OI related, including legs standing apart in the shower to hold my balance. The shower water pouring on my head might be related to both OI and vestibular imbalances.

So there you have it, exercise doesn't fix everything. Even highly trained female endurance athletes frequently experience menopause symptoms that affect their training and performance. Sleep problems, fatigue, joint pain, and weight gain are among the most disruptive issues reported.

Abstract Menopause is associated with several negative health concerns and common menopausal symptoms. Physical activity is essential to mitigate these negative effects, but menopausal symptoms may interfere with participation in physical activity. The purpose of this study was to determine the...

The novel sensor accurately measures markers such as cholesterol and lactate- crucial for early detection of diseases The team’s wearable, stretchable, hydrogel-based sensor overcomes the limitations of current methods that rely on biofluid samples, such as blood, urine and sweat. This makes it...

From the author of the paper: Lactate in Exercise vs Cancer: Same Molecule, Opposite Meaning Lactate is not a waste product. It’s a central player in both peak human performance and tumor progression. However, the context defines its role. In exercise, lactate is: -A regulated byproduct of...

Abstract Herein, we use lessons learned in exercise physiology and metabolism to propose that augmented lactate production (‘lactagenesis’), initiated by gene mutations, is the reason and purpose of the Warburg Effect and that dysregulated lactate metabolism and signaling are the key elements...

This was the case for me except I didn't see an ME doctor until a year of a half after viral onset. It was the quick relapse I experienced from returning to work that sealed my dx for disability benefits. I was diagnosed with PVFS/CFS and was considered "atypical" based on my symptoms at...

I used to get local monthly ME/CFS newsletters in the 90s before the internet and there were several stories of recovery from taking supplements and doing Qi gong, one recovered microbiologist started sending us lists of supplements to take. Then there was Dr. Jacob Teitelbaum's "nationally...

Dr. David Bell on CFS recovery discussing the three to five year mark I don't think that there is a high rate considering people do recover from PVFS within a few years.