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"We also include overlapping conditions when relevant (eg fibromyalgia, POTS, MCAS, EDS, chronic Lyme). Many patients sit at the intersection of these, and comparing patterns may be informative".

I've surrendered and blame everything on menopause because I no longer know what's doing what anymore. I never imagined it would be like this.

Interesting. My grandmother on my mother side suffered severe painful migraines and used to hide her medications under her mattress b/c family didn't want her taking higher doses, but she needed the higher dosages to manage. My history of migraine only occurred every 3-4 years and would...

The Phase 2 clinical trial is expected to be initiated by mid-2026 and to include the following features: -Multiple high doses of highly active monoclonal antibody VYD2311, an investigational antibody that has demonstrated in vitro antiviral activity across all clinically recorded variants of...

Release Date: January 20, 2026 https://investors.invivyd.com/news-releases/news-release-details/invivyd-and-spear-study-group-announce-plan-phase-2-study Phase 2 clinical trial will evaluate the safety, translational biology, and exploratory clinical efficacy of VYD2311 in people with Long...

The only positive symptom of menopause for me was that my migraines completely disappeared! I had them since age 12. I only experienced one aura during menopause but the headache never developed which was the first time in my life.

Hormonal shifts across life stages can make migraines better—or worse—for women. From menstruation to menopause, estrogen plays a key role in migraine triggers and relief. Study: Sex differences in migraine: bridging pathophysiology and clinical care in women

This would explain delayed PEM for me: "A low body temperature with feeling hot often points to your brain's thermostat(hypothalamus) being confused, possibly due to injury, illness (like sepsis), or hormonal shifts(like menopause), causing misdirected signals for sweating(feeling hot) while...

My new cold shivery chills symptoms are not PEM related as the forum subtitle implies btw. I feel overheated and dehydrated during delayed PEM but haven't experienced PEM in years by carefully pacing. To add, I took my temperature for one month every day over 20yrs ago for my...

Hi @curtnchrist I was going to start a thread on this exact new symptom! I've had ME/CFS for 35 years and this shivery chilly feeling started a month ago and I've been baffled by it myself. At first I thought it was age/ menopause related, but now I'm not so sure. I am still...

Let's not forget the importance of curiosity in our healthcare.

There was a Japanese woman who developed a deep emotional bond with her AI generated partner, and after 3 years of engagement she married him last year with smartphone and all the pomp. Something so farfetched years ago actually didn't seem that bizarre when I read her story. She maintains...

There was never any mention of these multiple diagnosis mentioned, connected or tagged on to ME/CFS in the early 90s until years later in the internet sphere. I might add that no one in my ME circle back then mentioned delayed PEM either, including my ME doctor, but he understood not to...

In the early 90s it was ME/CFS/Fibromyalgia until differential diagnosis involved ruling out other conditions with overlapping symptom.

Key Points Question What is the prevalence of central sensitization syndrome in postural tachycardia syndrome (POTS)? Findings This case-control study of 305 patients found a high prevalence (86.5%) of central sensitization syndrome in individuals with POTS. Meaning These findings suggest...

Published January 12, 2026 Open Access

I found this: The Southeast Australian foehn, also known as the Australian chinook or Great Dividing wind is a warm dry phenomenon occurring on the eastern slopes of the Great Dividing Range, causing significant drying and warming in coastal areas of NSW, Victoria and Tasmania.

Highlights Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS EBNA1 and ANO2 T cell responses are cross-reactive in humans and mice ANO2 and EBNA1 T cells have overlapping TCR repertoires and pathogenic phenotypes ANO2 immunization or ANO2-specific T cell...

Safety warnings for gabapentinoids, benzodiazepines, and non-benzodiazepines (z drugs) are to be strengthened to give doctors and patients clearer information about the known risks. The drugs are commonly prescribed to treat conditions such as neuropathic pain, anxiety, and insomnia and are...

Abstract Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthesis from trimethyllysine (TML) is essential, particularly for those who consume...