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  1. Mij

    Growing old versus ME/CFS—which is which?

    This Study just came out in case anyone's interested. New & Noteworthy. This study reveals that upper-body strength declines more rapidly in males than females with age, whereas trending results suggest that bone mineral density may show a stronger decline in female participants. We found...
  2. Mij

    News from Canada

    Just checked out their 'team'. Full of quackery. I had to look up Strength Coach, Fascial Stretch and Biosignature Practitioner. That's a new quacker to me.
  3. Mij

    Renegade Research

    Please sign up our next Clinician's Roundtable with @JackHadfield14 & @NBoydGibbins of @amaticahealth on Friday, Nov. 21! They'll discuss their MECFS and Long Covid 31 Marker and RNA Sequencing Tests plus their new Clinician Dashboard
  4. Mij

    Open Medicine Foundation (OMF)

    November 18, 2025 An Interview with Jonas Bergquist, MD, PhD, and Alain Moreau PhD The Heart of the Matter In an interview with Dr. Jonas Bergquist and Dr. Alain Moreau, two of OMF’s Directors, they talk about their main ideas behind ME/CFS, including an immune system that is too active in the...
  5. Mij

    A Study to Assess Anktiva in Patients With Long Covid-19. (INTERRUPT_LC)

    "[Patient name] is being treated with Dr. Patrick Soon-Shiong's therapeutic for long Covid, Anktiva. She's reporting her experiences on X. The subcutaneous injection works by getting the body's natural killer (NK) cells and killer T cells to go after viral reservoirs of Covid, which have been...
  6. Mij

    Menopause - news and discussion thread

    Due to "brain fog" BBC technology editor Zoe Kleinman had to hold notes during a recent live TV report "When I rather nervously shared a personal post about dealing with brain fog at work on the social network LinkedIn last week, I had no idea that it would have such an enormous impact. It's...
  7. Mij

    The compounding roles of gut-immune-brain axis and COVID19 in manifestation of idiopathic Parkinson’s disease, 2025, Ankita Das et al

    Abstract Parkinson’s disease (PD), for long has been understood as a neurodegenerative disorder confined solely to the brain. It is now emerging as a systemic illness marked by early gastrointestinal, immune, and neuroendocrine perturbations. This review challenges the traditional neurocentric...
  8. Mij

    Viral infections and the risk of neurodegenerative diseases: a comprehensive meta-analysis and systematic review, 2025, Liu et al

    It's hard to say in my case. Since menopause= worse sleep=worsens cognition on some days but improves on others. My balance/gait got a little worse after getting a vestibular virus 5 years ago, but now it's improving and I'm able to do leg lifts and standing on one leg for 60 seconds...
  9. Mij

    Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps, 2025, Rachel Kelly et al

    Abstract Neurotropic viruses affecting the central nervous system cause significant short- and long-term morbidity and mortality. Sequelae are extremely prevalent, with up to 50% of survivors experiencing neurological, neuropsychiatric, and behavioral issues. However, the immunopathological and...
  10. Mij

    Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secreted CCL5, 2025, Liu et al

    Summary Background Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk. Methods A cohort study was conducted to elucidate the associations among...
  11. Mij

    UK BACME ME/CFS Guide to Therapy 2025

    Overview of the therapy As the remit of the guide is active therapy the rationale for the rehabilitation approach is included. The World Health Organisation has defined rehabilitation as: "A process aimed at enabling people to reach and maintain their optimal physical, sensory, intellectual...
  12. Mij

    The itaconate shunt hypothesis

    My OAT 'energy production" panel: Citrate levels- 263 (ref ref range: 400-2000) Cis-Aconitase- 150 (ref range: 25-400) *within normal range Isocitrate- 37 (ref range: 50-300) 2-Ketoglutarate 1 (ref range: 5-80) Oxaloacetate 337 (ref range: 950-2800)
  13. Mij

    News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

    PolyBio cofounder Dr. Michael Van Elzakker described his lab’s research on neuroinflammation in Long Covid and pre-2018 ME/CFS. Via their PET scanning methodology, biological markers in patient samples (i.e. L-selectin, fibrinogen) are found to be correlated with neuroinflammation identified on...
  14. Mij

    COFFI - The international collaborative on fatigue following infection

    They searched the globe and found 2 patients who recovered, ok.
  15. Mij

    News from Canada

    Alberta declares a tuberculosis outbreak in Edmonton. This comes just days after Canada lost its measles elimination status—with Alberta having highest case concentrations.
  16. Mij

    How do we stop charities and influencers spreading bio-babble about ME/CFS?'

    Hopefully they will figure out the the exact pathophysiology of post-exertional malaise and delayed PEM and give us a name that represents that. Maybe the zebra fish have the answers.
  17. Mij

    Long-term use of melatonin supplements to support sleep may have negative health effects

    A study questions melatonin use and heart health bot don't lose sleep over it "But only certain countries require a melatonin prescription. It’s over-the-counter in the U.S., meaning Americans in the study might have used the supplements without it being recorded, said Northwestern University...
  18. Mij

    Dr Ron Davis - Updates on ME/CFS research - September 2019 onwards

    Ron Davies re: zebra fish "the key experiments is that they have been able to control the itaconate shunt and can turn it on, and when they turn on, the itaconate shunt the zebra fish swim slower. When they take one of their drugs that they found inhibit, and this is not necessarily gonna...
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