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Think these are the results relevant to ME/CFS (taken from Supplementary Table 3 - sheet B AII UKB PheWAS results). Human readable phenotype Raw phenotype beta se p nCases dataset Root broad.root refined 41202#G933#Postviral fatigue syndrome 41202#G933#G93.3 Postviral fatigue syndrome...

Thanks for spelling this out. So in ME/CFS one key area to study might be how neurons are activated intracellularly by cytokines that signal viral infection and induce (certain types of) sickness behavior. Then we would have to compare those pathways in ME/CFS and controls. Suspect this would...

Perhaps the virus infection and immune irritation of the vagus nerve is gone in ME/CFS but the viral signalling fails to shut itself off due to some defect in this pathway?

There was this 2023 study with autopsies of 27 people with COVID-19. The authors claim to have found signs of inflammation at the vagus nerve. Axonal mRNA analysis showed upregulation of interferon signalling but no signs of axonal damage. Sars-Cov-2 RNA correlated with these signs of...

Thanks. Would a local cytokine response somewhere around the vagus nerve be visible on scans, like the whole body PET scans by Michelle James.

What about the hypothesis that ME/CFS might be due to overactivation of the vagus nerve, might that be a good soluiton to the problem issue of massive sickness behavior without clear pathology or immune response?

I think the data from ME/CFS patients is also from the Keller study so that only the Long Covid results are new. There were quite a lot of tricky things about the Keller dataset (such as outliers influencing the results) so I wonder how they handled this here. I don't fully understand their...

From the paper (my bolding)

ZNFX1 is located on chromosome 20, where DecodeME found the strongest signal. It's near ARFGEF2, CSE1L and STAU1. It has been associated to general traits such as height, bone density and electrocardiogram morphology (amplitude at temporal datapoints), but not with other diseases yet...

interesting, thanks.

Congrats Adam on reaching so many views! Was only able to skim your text but it looked good. It's a bit long for newbies so perhaps some events (regarding the PACE trial for example) could be left out. On the other hand, it could also be useful for newcomers to have a comprehensive overview of...

This was published by Jeffery K. Taubenberger the new director of the National Institute of Allergy and Infectious Diseases (NIAID) and Jay Bhattacharya, the director of the NIH. Their brief paper in Nature Medicine explain the plans to update the NIAD mission to fit current challenges. Seems...

Good to see ME/CFS mentioned in this new NIAID mission statement:

'Preparing for tomorrow’s threats by enhancing our ability to help patients today.' 'For decades, National Institute of Allergy and Infectious Disease (NIAID) research has focused on three areas: HIV, biodefense/pandemic preparedness, and all other immunological and infectious diseases...

The example you post below doesn't look like it set the bin width to 1 though. And if you have more than 2 groups, it becomes harder to see if they are all overlapping.

Think what you show is called a dot plot. Histograms are normally used to group different values on the x-axis. It turns continuous x-values in categories or bins so that each data point is no longer visible, just the frequency of each bin.

Well spotted, thanks. Looks like there might have been a small effect for complex working memory (2-Back Task; TWOB). But not for the Digit Span Backward Not sure why this paper wasn't included. They review said "Database searches were conducted on 18 April 2024 and on 6 November 2024" and...

Think this Dutch ME/CFS study will look into this but they plan to do measure a lot of things so perhaps the neurocognitive testing will not be very elaborate. https://projecten.zonmw.nl/en/project/investigating-metabolic-and-neuropathological-interactions-address-cognitive-symptoms-mecfs

There is quite a lot of heterogeneity itself though, goes to minuscule to enormous. A lot of older studies as well. I think it would be good to have a newer, bigger study to pinpoint where cognitive deficits in ME/CFS lie exactly. My guess is that the tests needs some endurance aspect, that...

I prefer these jitter plots because they show each datapoint, which isn't the case with a histogram.