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This is such an important point that I want to mention it. PEM or PEF, respectively, or PENE is not a certain symptom, it´s specific patterns of appearance of symptoms. I remember to have read in the PACE trial paper, that it would be astonishing that GET helps as PEM is (or "was") considered...

Yes, the problem with PACE and studies like that is even bigger than being prone to be biased because of a placebo effect. The danger is that they rather measure the hope which they hold out to the patients. One may see that such a design is open for certain forms of sadism, for charlatanry...

Self-causation?;)

The theory is intuitively wrong, even at its most, and there are no empirical hints either. A possible explanation: Any living being wants success. This should even be even the definition of an intention. And the success is wanted for itself. Pain diminishes the intention, or even better, is...

I answered as social worker, which I have been: Q: Please tell us what first comes to your mind when you hear the term pain catastrophizing. A: For me, having had chronical pain myself for 15 years, there hasn´t been any catastrophizing. It was there and I tried not to pay attention. With...

Mental illnesses are real, and it is important to know of their existence, I think. There is no clear border between mentally ill and mentally healthy. Homosexuality had been classified as such an illness, but the classification itself should display mental illness. It is not without sense to...

No, I haven´t, instead I have a philosophical and carpendrical background, and this combination makes that I am interested in nerves with all their axons. If I may say this, the carpendry has given me a good idea, to put up nerves (their connections rather) again (which implicates that there has...

Here in Germany so far everything stays low, regardless of relaxions. The states are now acting almost completely at their own will, but I guess no essential differences will be seen. The spread of the virus is a riddle to me. Maybe in autumn we will see a second wave, and then countries...

Yes, but it can, I think, and for sleep patterns it should be well known (I should check it out again though!), say from here: Thalamic dual control of sleep and wakefulness. Gent et al 2018. I currently cannot remember well what I knew, but this short article with new insights I found...

As if there would happen progress now, indeed interesting. Descartes theory and related ones probably never haven´t been that much in charge, not say in the 17th century and not say in shamanism. Maybe in the pyramids. Best might even be to sidestep the considerations on body vs mind, and simply...

RE: Benzos (Benzos modulate GABA receptors. The GABA channels bring then more negative charged chloride ions into the nerve cell when the receptor is bound at. GABA are distributed all over the brain but especially in some areas in the basal ganglia. Positive charged sodium and calcium ions...

Kind of free time. If I would be them and had time to investigate, I would put my honest imagination and fantasy into it. A play with possibilities, as every scientist would like to enjoy, but its every time the same noisy anything. Its even more clueless than incompetent.

Might be key for my ME, according to some recent experiences I still have. from the introduction

The problem is that the basic mistake doesn´t happen at the level of control but at the basis of all that research. And a lot of research says roughly the same - which sounds good. The controllers, now, are not the researchers, instead the researcher want to fulfill any standards. And may...

Thank you for explaining, @Snow Leopard. So then (b) should not be able to be used to indicate the one or the other cause (or better main cause). And with any feedback loops (c) between muscle and say spinal cord, maybe in MS, the interesting question arises why this would be, when e.g. MS is...

But it´s doubled easy. Even if there is a centrally mediated disorder indeed, well hinted or maybe even confirmed (if possible) by any improved method your are requesting, it does not say that this centrally mediated disorder is driven by any proportion that can be influenced psychologically...

Very interesting. Also this:

I think the attempt is comparable not too bad, but it´s not "exactly" what happens. It´s mere an allegory, and therefore the analogy cannot be exact, and may be misleading ... I think one should ask, what would nature have taken by chance to evolve an "alarm", which later could generate in some...

A version fitting better to the original may be (if it is not too clumsy): I think it involves the distinguishing of being affected through themselves or through others (coming from the one or another), and of taking it up as something, so making it. And this then allows for the difference of...

In my experience not my mood but my ability to engage can slow down and even suddenly disrupt, but this is an operative inability, not a motivational one. If we compare this with depression, then, although it is easily thinkable that depression has an organic cause, we see that depression is an...