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If someone could show that these data are wrong, I would be curious. Ivor Cummings, 9.8. about US at 22:00, about south america right before some prediction for the rest of the year at 33:00

But you must be able to distinguish. Excess mortalitiy is still high, as of two weeks ago, but has gone significantly down. So a death with covid-19 does not equal a death because of covid-19. It could already be that other causes of the deaths have risen high. I see though that the US most...

In Spain and France new infections are almost as high as in late winter/early spring, if I was not blind. But there is not anymore a high death rate. Another question is of course on long term outcomes, but if this would be a massive problem there would be data, I guess. Taken together...

Hahaha, they "strongly" endorsed an interpretation to a model which in itself consists of such, or rather this, interpretation (otherwise the complaints wouldn´t reflect a "conversion").

I found this article, re: neurovascular coupling, good to get an idea: Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus Cátia F. Lourenço et al 2018 PMC6056650

Thank you for helping me up, @rvallee. I had forgotten to drink anything and was a bit dry at time of posting.

They don´t seem to have in mind the following findings on Protein kinase RNA-activated (PKR), at least these findings are not listed in their literatur: Unravelling intracellular immune dysfunction in [CFS]: Interactions between protein kinase R activity, RNase L cleavage and elastase activity...

Incredible helpful, such effort.

I know bone pain, too, only sometimes, on the surface of especially the legs. It seems that all my pain is purely neurological, and it behaves in some sense indeed interesting.

No, for example, you might miss-wire you nerves. The machinery of feeling could be ill. And the worse you would make it, the more difficult would it be to reverse it.

Sarkar et al 2019: Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells. Zhao et al 2019: Manganese induces neuroinflammation via NF-κB/ROS NLRP3 pathway in rat brain striatum and HAPI cells I just googled these two terms (though I think I...

This might be interesting: Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses Wang et al 2018

No, it is not obvious. It is empirical clear that drugs can change the feeling of "having energy" or "not having energy". And only because there isn´t any drug that has been found to influence any fatique-feelings in CFS on any longer run, this doens´t mean that there is really no energy. The...

It is utterly difficult to describe (including "measuring") fatique: I could work half time but had pain. Another guy is bedbound but has no pain. When I managed to slowly loose my pain, I couldn´t work anymore, mainly because of cognitive failure, also inducible by moving too much around...

Here is another article on this theme: Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes Wang et a 2010 from the intro, referring what was known (my pragraphs) And then their finding is, of course and as in the title indicated, that...

Nerve issues do not equal psychological issues. I learned the following method from @rvallee: Repeat several times: Nerve issues do not equal psychological issues. Nerve issues do not equal psychological issues. Nerve issues. Do not equal. Psychological issues.

It would be more interesting, of course, to have a mechanism underlying fatique itself.

Very interesting, thank you.

An "interoception" does for sure not work like a perception of the outer environment. If it is not too annoying: A perception of the outer world can be false or true. The perceived thing shows a dependence on the being which is perceiving - though obviously it cannot create what it wants, if...

I have been told that nutrition would influence the amount of MnSOD, but I don´t know how good the evidence is. Very interesting, of course. I ever had thought though that this crucial enzym won´t undergo any significant changes under physiological circumstances. But I Know that in some cancers...