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The variation in the day is why I'd like to use it "right now". I think the FUNCAP might be influenced by how someone is feeling "right now" anyway, maybe not completely but I'd say it would be a factor. I like the idea of perception of consequence to doing activity as a measure of how someone...

The guidelines for the history of the disease in Australia have pretty much been that a diagnosis of CFS requires 6 months of fatigue. That might have something to do with it. Prevalence numbers range from 0.25% to 1% of the population, probably depending on the diagnosis used. 25m people...

Well done Simone! :thumbup:

Asparagine is simply aspartate with an NH3 added. Alanine is pyruvate with an NH3 added. Adding Asparagine or Aspartate would probably produce a similar outcome though asparagine comes with more NH3.

I don't know if they do know what's happening in the pathway. Statisticians typically stick to reporting facts rather than interpreting them in my experience. My guess is that the conclusion of asp and asn is largely driven by what they saw in the pathway. But yes, that doesn't seem to be...

Yes during hyperventilation you breathe out more CO2. If TCA cycle is constantly slower then you'd have a mechanism of reduced CO2 production and excessive release. CO2 is important for CBF, balancing blood pH and digestion.

Pathway analyses are a bit clunky. They are simply a guide to suggest that metabolites in this network of pathways are enriched. They help to focus ideas. Aspartate and alanine pathway includes aspartate and asparagine.

I imagine the cells that are lifelong would be of particular interest in this theory.

I think mitochondria are functioning fine broadly, they are responding to something though. As @DMissa points out, they could be responding to a signal.

I think the pain aspect with impact on SFN is fascinating and important. Really that's the stand out piece for me. They took IgG from patients that experienced pain and put them in mice, which then created increased pain in the mice. They took a cohort from these mice to look at small fibers...

CO2 is produced from the TCA cycle in mitochondria. It's a byproduct but it plays a lot of important role. Less TCA cycle gets you less CO2. Hyperventialtion pushes our more CO2. Both things happen in ME, both would work to reduce CO2. CO2 + H2O gets you HCO3- and H+ This highlights the major...

I guess a good question might be this.. Orthostatic Intolerance can mean many different things. Do ME/CFS patients have more of one type of OI than is expected in the non-ME OI population?

Great discussion in here. A lot of focus on oxygen delivery, I think too much focus actually. More interested in CO2 and its impact on blood flow. Additionally, blood flow is important in removing and providing metabolites. The removal process is underrated here, it could actually be the...

I spoke to Satish Raj about this at a conference. POT doesn't come with the syndrome. It's possible that POT is highlighting tachycardia that can effectively compensate and maintain blood flow (especially CBF). POTS might be when the tachycardia happens but isn't effective enough to maintain...

We're interested in assessing this questionnaire's ability to assess someone "right now" or "within the last 1-2 day period' as opposed "average day of the last month". What do people here think of its applicability on that short time period?

I think this is an interesting paper. I would be interested in the outcome of this treatment concept as well. Difficult part is working out how to get metabolites like these to the tissues of need.

ANA levels have been observed to be elevated in ME cohorts on several occasions from memory. It would be good to know if this is a predisposing factor or an issue of under diagnosing other autoimmune issues or if it's a developed phenomenon. I will chat to Wenzhong next week and ask him about...

Very true. I meant it in a positive way. I'm typing pretty quickly on here. I can't even think of the right word, it seems like challenging ideas has negative connotations in English. Perhaps I will just say "not just agreeable".

Not everyone deals with criticism the same way. Some researchers are unfairly disliked and some are unfairly adored. I think both are the wrong reasons to work or not work in this field. If you understand what you are doing and can back it up then I see no reason to be emotional about it...

Well for research it would be very valuable to have a tool that could predict a patient day. The waking blood samples is fasted and a 24 hour urine collection is all day, both are valuable sample types for standardising marker measures. if you were to try capture either of these on a certain...