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a) There's another process going on in you? b) Could instant muscle burning happen due to neuropathies (of whatever kind)? c) They're not measuring the right things? (Whatever right is....) d) Many other things? Yes? See mitochondriopathies. Or is the production of ATP via glycolysis always...

It seems muscle weakness is a well-known symptom in neuropathies (especially (inherited) peripheral neuropathies) which includes fast fatiguability. As a consequence, orthopaedic issues are not uncommon, like scoliosis and other consequences for joints, tendons etc. due to too weak and/or fast...

I agree that medicine wants to give its best. It can't do wonders. But medical errors are about doing errors that could have been prevented if common state of the art had been applied. The Hippocratical Oath goes even further.

@Sisyphus, I can only refer to Germany where medical errors aren't recorded properly. E.g. there are ways to speak away a medical error, or just to redefine it so that it doesn't have to be counted. From judicial view, it is very difficult to prove a medical error. That doesn't mean there wasn't...

Do you know how it works biochemically? Let's say in high doses it promotes apoptosis (I'm just inventing) and in lower doses...?

I have to agree. Somehow this study makes me suspicious. This doesn't sound like a cardiopulmonary test at first glance. It leaves me confused. Or they use strange language. During a cardiopulmonary test, you usually increase resistance incrementally until exhaustion (so it goes beyond...

In the mitochondrion signaling, many, many proteins and ions are involved - anywhere on that path, something can go wrong. There is signaling between the ER and the mitochondrion (via the MAM = mitochondrion associated membrane), whereby both lie in close proximity so that Ca signals from the ER...

At least for AD (and I remember PD and ALS were also discussed), research of the past < 5 years hints at a role of ER calcium homeostasis, and a disruption there seems to be the cause of why proteins misfold (in AD, it's amyloid beta proteins) and then accumulate. Details of Ca signaling...

I react to sun light, or, more precisely, UV light, via eyes and skin. (It causes brainfog, disorientation, headache/migraines, a bit like PEM. Sometimes the skin burns when the sun shines on it.) Jaime, do you think this could be due to UVA and UVC light, not UVB? It's why I didn't use tanning...

Thank you @dave30th! Always at the right time.

Maybe they're leaving their "unhelpful illness beliefs" behind and saddle up to "it's biological; AND CBT/GET help". Give them want they want - but don't do it, really. Maybe it's the step into the direction to use CBT/GET as a cure for anything and everything.

I have read a bit about fractalkine. Fractalkine seems to play a neuroprotective and an inflammatory role. Here, https://www.nature.com/articles/nn0706-859 the authors show: For this, the authors ablated the fractalkine receptor (which sits on microglial cells). Other papers show or discuss...

Does somebody know if Fractalkine was studied in ME? Edit: Found it. Sorry. Edit2: Jarred Younger looked at fractalkine?

I came across heat shock proteins, and found this interesting: https://www.physiology.org/doi/full/10.1152/japplphysiol.01267.2001

Thank you @Peter. I see my post was unclear. I mean why do think Yes, absolutely.

I never heard about that. Any links so that I can inform myself?

0,1-0,2% are crazy numbers? What would be more correct? And why?

I agree that 'stress' in the common sense of today (psychological stress) is not the root cause, which is my personal opinion. Klimas speaks of several stressors, like viral infection. "Stress" could be a contributor. I came across endoplasmic reticulum stress which is defined as the increased...

They had 200 volunteers. If they exclude up to around 70%, no wonder it gets difficult. Edit: One mustn't forget problems regarding travel. Most people with ME cannot travel, and researchers won't come to you, or there is no remote option.

Maybe sleep dìsordered breathing is part of ME/CFS? Maybe those people shouldn't be excluded? ME/CFS is not a sleep disorder, the main symptoms are different. ME won't disappear if the disordered breathing is solved. What some researchers maybe should understand is that they're doing the job of...