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I recall Simon M, in a review of a previous metabolic study (by Hanson's group), writing something along the lines of --- we [this study] didn't find anything --- if we were to repeat this study then we'd introduce a stressor --- like exercise. So they've now done that follow up study i.e...

Haven't read the study (or even the abstract) but my knee jerk reaction is that they could have selected using actimetry combined with a diagnosis of ME/CFS. There are probably plenty of studies which demonstrate how actimetry could be used e.g. Friedberg* and (didn't think I'd even quote this)...

Yea carnitine is interesting to me. My wife has a neurological condition and low carnitine turned up in one of her tests; so she supplements with carnitine now. Our daughter has disabling fatigue - a doctor has commented that it looks like ME. If carnitine is relevant then Chris Ponting's GWAS...

Hi thought I'd flag this up here. In their response, to an EU Parliamentary Question [asked by Günther Sidls (MEP)], the EU Commission stated that it will "The Commission will support a [scoping] study to help identify high burden conditions [like ME/CFS & Lyme - long covid?] that are...

Just wondering how they are going to reword it -- Rosetta Stone-- some interesting translations/euphemisms --- for pain in the flesh substitute ----?

Good to hear the harms being highlighted - I'd commented here* that it is a lucrative scam (for those at the top) - this illustrates the harm through the creation of false hope/beliefs and inevitable disappointment when the "treatment" doesn't work and worse still, they're blamed ----...

"Jesus, my back is itching, isn't yours?" Still making me laugh - thanks.

Check out the comments here* if TPPP1 is implicated then there may not be a clear biomarker in blood or even cerebro spinal fluid (not that accessible). I think Angela Vincent mentioned to me once that there'd need to be a technological discovery to understand ME/CFS - check out comments in this...

Reminds me of a comment from Brian Hughes, during his talk to the Norwegian ME Association* - (from memory) if ME/CFS is psychological then you would expect psychological treatments to work - but the evidence is weak, typically from unblinded studies with subjective outcome criteria ---. So...

Just thought I should highlight that although the hunt for infections (e.g. the potential link to EBV) could be investigated by e.g. looking at the US Army data - I'm not aware of any proposal to do that. So although there are potential research areas, lack of funding etc. mean that these may...

If you hunt around this forum then you'll find some discussion re EBV in MS [large US Army study] - how that could be replicated for ME/CFS.

I'm no expert but--- I think that's why GWAS (Chris Ponting's study) and indeed the recently published, much smaller, Norwegian study* are important i.e. they're looking for cause, rather than downstream events (consequence). I recall this comment* since it indicates that the way in (to...

Awesome presentation, just listened to it - calm, coherent, informed --- thanks to the Norwegian ME Association & Brian Hughes

Too early to say but there are some interesting comments here* re a potential cause of ME/CFS uncovered by a genetic study (GWAS) --- something like this, an intracellular problem, wouldn't necessarily give an easy to detect signal in blood or whatever. To be honest I think something like this...

We're laughing here i.e. "bejeebus" - do you have Irish roots?

"UK: NIHR funding opportunity: 22/37 Non-pharmacological interventions for fatigue management in adults with long-term health conditions" I laughed when I read the title. Perhaps someone like @Brian Hughes Could consider whether anything meaningful (like funding for an MSc project) could come...

Surely the assumption is that anyone who definitely had Lyme, and who has disabling fatigue (post Lyme but not before), is suffering from post Lyme fatigue not ME/CFS? Is this publication suggesting that you are more likely to get ME/CFS after Lyme? Tangential - as often! Wonder if they ever...

Interesting - I wonder if the research into Alzheimer's may help - understanding how to investigate abnormalities in brain cells - potential ways to treat. Sounds optimistic - understatement, but they may have come up with techniques/technologies which could help to understand e.g. TPPP1...

If you mean a large scale GWAS project, in ME/CFS, then yes, these have been carried out in a number of other, higher profile, illnesses - which does beg the question why they weren't funded earlier ---- thankfully, the expert MRC group Jonathan sat on, identified the opportunity and Chris...

Hopefully you'll get a better answer than this. Not sure if you noticed this comment from Jonathan (previous page): "I think its effects may only be found within cells. So yes, this would explain exactly why the mechanism of me is so hard to observe. Tubulin is a polymerising protein that...